Mucoactive therapy in the practice of an otorhinolaryngologist


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Abstract

This article is devoted to the use of mucoactive therapy in the practice of otorhinolaryngologists. In particular, the possibility of using ambroxol. The restoration of drainage function of the upper respiratory tract is an important point in the treatment of acute sinusitis and exacerbation of chronic sinusitis. The appointment of mucoactive drugs, such as ambroxol, allows increasing the effectiveness of mucociliary clearance, which is impaired due to overproduction of viscous secretions, as well as inhibition of motor function of ciliated epithelium.

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About the authors

Eduard V. Sinkov

Sechenov First Moscow State Medical University (Sechenov University)

Department of Ear, Nose and Throat Diseases, N.V. Sklifosovsky Institute of Clinical Medicine; Cand. Sci. (Med.), Associate Professor at the Department of Ear, Nose and Throat Diseases 6, build. 1, Bolshaya Pirogovskaya str., Moscow 119435, Russian Federation

V. M Svistushkin

Sechenov First Moscow State Medical University (Sechenov University)

Department of Ear, Nose and Throat Diseases, N.V. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

T. Kh Shadyev

Sechenov First Moscow State Medical University (Sechenov University)

Department of Ear, Nose and Throat Diseases, N.V. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

I. V Stozhkova

Sechenov First Moscow State Medical University (Sechenov University)

Department of Ear, Nose and Throat Diseases, N.V. Sklifosovsky Institute of Clinical Medicine Moscow, Russia

References

  1. Пискунов Г.З. Физиология и патофизиология носа и околоносовых пазух. Российская ринология. 2017;25(3):51. doi: 10.17116/rosrino201725351-57.
  2. Карпищенко С.А., Алексеенко С.И., Колесникова О.М. Мукоактивная терапия. Перспективы применения в оториноларингологии. Consilium Medicum. 2017;19(3):44-9.
  3. Rubin B.K. The pharmacologic approach to airway clearance: mucoactive agents. Respir Care. 2002;47(7):818-22. doi: 10.1016/j.prrv.2006.04.198.
  4. Гаращенко Т.И. Мукоактивные препараты в лечении заболеваний околоносовых пазух. РМЖ. 2001;19:806.
  5. Клячкина И.Л. Новые возможности лечения кашля. Вестник оториноларингологии. 2015;80(5):85-90. doi: 10.17116/otorino201580585-90.
  6. Чучалин А.Г. Рациональная фармакотерапия заболеваний органов дыхания. М., 2013. 872 c.
  7. Mata M., et al. Respiratory Syncytial Virus Inhibits Ciliagenesis in Differentiated Normal Human Bronchial Epithelial Cells: Effectiveness of N-Acetylcysteine. PLoS. One. ed. H.W Chu. Publ. Libr. Sci. 2012;7(10):e48037. doi: 10.1371/journal.pone.0048037.
  8. Li X., et al. Ambroxol hydrochloride combined with fluconazole reverses the resistance of Candida albicans to fluconazole. Front. Cell Infect Microbiol. 2017;7(APR):1-8. doi: 10.3389/fcimb.2017.00124.
  9. Ueda N., et al. Inhibitory effects of TNF-alpha and IFN-gamma on ciliary beat frequency of cultured human sinus epithelial cells and its modulation by ambroxol hydrochloride. Pract Otol Soc Pract Otolaryngol. 2000;93(2):167-73.
  10. Malerba M., Ragnoli B. Ambroxol in the 21st century: Pharmacological and clinical update. Expert Opin Drug Metab Toxicol. 2008;4(8):1119-29. doi: 10.1517/17425255.4.8.1119.
  11. Scaglione F., Petrini O. Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive? Clin. Med. Insights Ear, Nose Throat. 2019;12:1-9. doi: 10.1177/1179550618821930.

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