New possibilities for conservative management of patients with HPV-associated diseases of the cervix of the uterus

The article presents modern approaches to the treatment of cervicitis associated with HPV, mild cervical intraepithelial neoplasia (CIN 1) based on modern ideas about the etiology and pathogenesis of this disease. It is noted that inflammation is a risk factor for HPV persistence, in addition, expression and the increased estrogen 16α-hydroxyestrone level mutually reinforce each other, accelerating the processes of tumor transformation in the cervical epithelium. It has been established that the level of abnormal epigenetic modifications, in particular, the level of promoter DNA methylation of antitumor defense genes, is steadily increasing with the progression of CIN and is characteristic of an integrative or transforming form of HPV infection. Searching for gentle treatment methods, for CIN 1 revealed that the substance diindolylmethane is able to simultaneously block many molecular mechanisms in HPV-transformed cervical epithelial cells that mediate pathological cell proliferation and subsequent carcinogenesis. The results of the studies have demonstrated the effectiveness and safety of the cervicon-DIM preparation containing diindolylmethane, targeting inflammation, the CIN pathogenesis and the mechanisms of further tumor transformation. Thus, a new therapeutic approach based on the use of diindolylmethane, acting on infected cells, apoptosis, and key molecular mechanisms of pathological processes in the tissues of the cervix uteri, will significantly reduce the number of poor outcomes and prevent the transformation of CIN into cervical cancer.

CIN-1, human papillomavirus, cervicitis, cervical cancer, mild cervical intraepithelial neoplasia, CIN 1, diindolylmethane, cervicon-DIM