Modern approaches to the correction of the pathology of the digestive system in patients with atopic dermatitis
- Authors: Kosheleva I.V1, Shadyzheva L.I1, Yatsyna I.V2
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- F.F. Erisman Federal Scientific Center of Hygiene
- Issue: Vol 27, No 8 (2020)
- Pages: 42-46
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312761
- DOI: https://doi.org/10.18565/pharmateca.2020.8.42-46
- ID: 312761
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Abstract
Background. Atopic dermatitis (AtD) is one of the most common chronic recurrent dermatoses with multifactorial pathogenesis. It is known that increased absorption of food allergens is supported by the pathology of the digestive system, which in turn supports the chronic course of AtD and the progression of skin manifestations. Objective. Assessment of the presence and severity of pathological changes in the digestive system, as well as monitoring of the effectiveness of the treatment by determining the blood serum levels of natural autoantibodies (AB) against tissue-specific antigens of digestive system using enzyme-linked immunosorbent assay (ELISA) in patients with AtD. Methods. The study included 102 patients of adolescence and young age (15 to 44 years old) with disease duration from 15 to 44 years, 55 (54%) women and 47 (46%) men with mild (49 people) and moderate (53 person) course of disease, without complaints and history of the pathology of the digestive system. Patients were divided into two groups, matched by gender and age composition and clinical manifestations of AtD. To determine the blood serum levels of natural antibodies against tissue-specific antigens of digestive system in patients with AtD, solid-phase ELISA was used. Treatment of patients with AtD was carried out in accordance with the Federal clinical guidelines for the management of patients with AtD. Results. As a result of the study, it was found that patients with AtD have significant deviations in the levels of natural antibodies to membrane antigens of the digestive system (liver, stomach and small intestine), indicating the likely presence of subclinical metabolic disorders, and in adolescent patients (15-18 years) they are most pronounced. Conclusion. Violations identified by ELISA confirm the feasibility of a comprehensive treatment of patients with AtD without clinical manifestations of pathology of the digestive system.
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About the authors
I. V Kosheleva
Russian Medical Academy of Continuous Professional EducationDepartment of Dermatovenerology and Cosmetology
L. I Shadyzheva
Russian Medical Academy of Continuous Professional Education
Email: leyla.shadyzheva@gmail.com
Department of Dermatovenerology and Cosmetology
I. V Yatsyna
F.F. Erisman Federal Scientific Center of HygieneDepartment of Adolescent Dermatology
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