Long-acting somatostatin analogues in the treatment of children with congenital hyperinsulinism. Literature review
- Autores: Savkina A.R.1, Kareva M.A2, Melikyan M.A2
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Afiliações:
- Pirogov Russian National Research Medical University
- National Medical Research Center for Endocrinology
- Edição: Volume 27, Nº 9 (2020)
- Páginas: 38-41
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312782
- DOI: https://doi.org/10.18565/pharmateca.2020.9.38-41
- ID: 312782
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Resumo
Congenital hyperinsulinism (CHI) is a hereditary disease characterized by inadequate insulin hypersecretion by pancreatic ß-cells, leading to severe hypoglycemia. One of the most common causes of CHI is the inactivation mutation of the ABCC8 and KCNJ11 genes. The first-line therapy for CHI is diazoxide. However, there are forms resistant to this treatment. In such cases, somatostatin analogues (SA) are used. For this article, an analysis of relevant literature in the field of treatment of CHI was carried out. Clinical observations of foreign authors on the successful use of long-acting SA in CHI are presented. It is concluded that SA remain the leading drugs for the treatment of diazoxide-resistant forms of CHI. The scientific community gives particular preference to long-acting forms of SA proving their effectiveness and safety in studies.
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Sobre autores
Anastasiya Savkina
Pirogov Russian National Research Medical University
Email: ifeel1996@mail.ru
sixth-year student of the faculty of pediatrics 1, Ostrovityanova str., Moscow 117997, Russian Federation
M. Kareva
National Medical Research Center for EndocrinologyMoscow, Russia
M. Melikyan
National Medical Research Center for EndocrinologyMoscow, Russia
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