Probiotics in the treatment of acute intestinal infections in children


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Abstract

Background. Acute intestinal infections (AEI) remain one of the pressing health problems, causing significant economic damage both in our country and around the world. The incidence of AEI in children is significantly higher than in adults, with the largest number of their registered cases occurring in children under the age of 7 years. Objective. Analysis of published studies of the effectiveness of probiotics in the treatment and prevention of AEI in children and assessment of the strain sensitivity of a number of Campylobacter bacteria, common causative agents of AEI, to various probiotic strains. Methods. The analysis of publications on the clinical use of probiotics in AEI in children in PubMed, EMBASE and Web of Science systems from December 2000 to June 2020 was carried out. For the study of anticampylobacter activity, the following probiotics were used: Enterococcus faecium L3, Lactobacillus plantarum 8 R-A3, a mixture of Lactobacillus acidophilus, Enterococcus faecium SF68, Bifidobacterium bifidum and Saccharomyces boulardii. Results. Analysis of literature data shows that the treatment and prevention of AEI are the most reliable indications for the use of probiotics, including in children. Conclusion. At the moment, there is significant evidence of the effectiveness of probiotic strains both in the treatment and prevention of intestinal infections. Problems with the dosage and duration of probiotic therapy in various nosological forms of AEI in children remain not fully resolved. Multi-strain probiotics require further research. Differences in the sensitivity of campylobacter to various probiotic strains indicate that for patients with severe forms of acute intestinal infections, it is advisable to select an individual probiotic to increase the effectiveness of complex therapy.

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About the authors

Konstantin D. Ermolenko

Pediatric Research and Clinical Center for Infectious Diseases

Email: ermolenko.kd@yandex.ru
Cand. Sci. (Med.), Researcher at the Department of Intestinal Infections 9, Professor Popov str., St. Petersburg 197022, Russian Federation

N. P Boldyreva

Institute of Experimental Medicine

St. Petersburg, Russia

E. I Ermolenko

Institute of Experimental Medicine

St. Petersburg, Russia

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