Possibilities of prevention and drug therapy of gastroenterological pathology after viral intestinal infections in children
- Authors: Ermolenko K.D.1, Gonchar N.V1,2
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Affiliations:
- Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia
- North-Western State Medical University n.a. I.I. Mechnikov
- Issue: Vol 27, No 9 (2020)
- Pages: 86-91
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312803
- DOI: https://doi.org/10.18565/pharmateca.2020.9.86-91
- ID: 312803
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Abstract
Background. Acute intestinal infections (AII) remain one of the pressing health problems, with the largest number of registered cases occurring in children under the age of 7 years. Functional gastrointestinal disorders (FGID) occupy a leading position in the structure of diseases of the digestive system in children of various ages, including in AEI convalescents. To date, however, only a few works highlight the problem of preventing the development of FGID after AII in children. Objective. Evaluation of the symptoms and frequency of the development of post-infectious functional gastrointestinal disorders after viral gastroenteritis in convalescent children, as well as assessment of the efficacy of their treatment using probiotics. Methods. The study included 147 children undergoing treatment for severe forms of AII (Clark’s index at least 14 points) at the Department of Intestinal Infections, Pediatric Research and Clinical Center for Infectious Diseases FMBA of Russia. There were 63 (42.8%) boys and 84 (57.2%) girls. Reconvalescent AII was observed on an outpatient basis for 24 months, detecting FGID. Drug treatment of FGID was carried out in 5 groups of AII convalescents for a month with Trimedat (n=11), Acipol (n=11), Bifiform (n=10), Enterol (n=10) and Trimedat+Acipol (n=7). Results. It was found that after the viral AII, the leading complaints in the follow-up period (1 year) included abdominal pain and constipation. Symptoms of «little diarrhea» and rapid satiation were less common. The maximum frequency of the symptom onset was observed from the 3rd to the 6th month of follow-up. The greatest positive effect in the treatment of post-infectious FGID was achieved as a result of a course of therapy with Acipol and Acipol in combination with Trimedat. Conclusion. The data obtained indicate the need to identify groups at increased risk of FGID development after AII among children, with subsequent long-term observation of convalescents in order to timely adequate therapeutic correction and prevention of possible complications.
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About the authors
Konstantin D. Ermolenko
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia
Email: ermolenko.kd@yandex.ru
Cand. Sci. (Med.), Researcher at the Department of Intestinal Infections 9, Professor Popov str., St. Petersburg 197022, Russian Federation
N. V Gonchar
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia; North-Western State Medical University n.a. I.I. MechnikovSt. Petersburg, Russia; St. Petersburg
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