Механизмы нарушения проницаемости эпителиального барьера при воспалительных заболеваниях кишечника


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Аннотация

Появляется все больше свидетельств того, что повышенная проницаемость эпителиального барьера может иметь важное значение в патогенезе воспалительных заболеваний кишечника (ВЗК). В данном обзоре рассматриваются современные представления о строении эпителиального барьера и молекулярных механизмах, лежащих в основе повышенной кишечной проницаемости. Особое внимание уделено структурным изменениям плотных контактов (TJ) и адгезионных соединений (AJ) толстокишечного эпителиального барьера у пациентов ВЗК.

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Об авторах

Г. Н Тарасова

Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской области

Ростов-на-Дону, Россия

А. А Яковлев

Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской области

Ростов-на-Дону, Россия

А. Д Зубова

Медико-санитарная часть МВД России по Ростовской области

Ростов-на-Дону, Россия

С. М Нухова

Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской области

Ростов-на-Дону, Россия

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