Механизмы нарушения проницаемости эпителиального барьера при воспалительных заболеваниях кишечника
- Авторы: Тарасова Г.Н1,2, Яковлев А.А1,2, Зубова А.Д2, Нухова С.М1,2
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Учреждения:
- Ростовский государственный медицинский университет
- Медико-санитарная часть МВД России по Ростовской области
- Выпуск: Том 28, № 2 (2021)
- Страницы: 30-35
- Раздел: Статьи
- URL: https://journals.eco-vector.com/2073-4034/article/view/313077
- DOI: https://doi.org/10.18565/pharmateca.2021.2.30-35
- ID: 313077
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Аннотация
Появляется все больше свидетельств того, что повышенная проницаемость эпителиального барьера может иметь важное значение в патогенезе воспалительных заболеваний кишечника (ВЗК). В данном обзоре рассматриваются современные представления о строении эпителиального барьера и молекулярных механизмах, лежащих в основе повышенной кишечной проницаемости. Особое внимание уделено структурным изменениям плотных контактов (TJ) и адгезионных соединений (AJ) толстокишечного эпителиального барьера у пациентов ВЗК.
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Об авторах
Г. Н Тарасова
Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской областиРостов-на-Дону, Россия
А. А Яковлев
Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской областиРостов-на-Дону, Россия
А. Д Зубова
Медико-санитарная часть МВД России по Ростовской областиРостов-на-Дону, Россия
С. М Нухова
Ростовский государственный медицинский университет; Медико-санитарная часть МВД России по Ростовской областиРостов-на-Дону, Россия
Список литературы
- Spaendonk H.V., Ceuleers H., Witters L., et al. Regulation of intestinal permeability: The role of proteases. World J Gastroenterol. 2017;23(12):2106-23. doi: 10.3748/wjg.v23. i12.2106.
- Bischoff S.C, Barbara G., Buurman W., et al. Intestinal permeability - a new target for disease prevention and therapy. BMC Gastroenterol. 2014;14:189. doi: 10.1186/s12876-014-0189-7.
- Gerova V.A., Stoynov S.G., Katsarov D.S., et al. Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test. World J Gastroenterol. 2011 ;17(17):2211-15. doi: 10.3748/wjg.v17.i17.
- Vivinus-Nebot M., Frin-Mathy G., Bzioueche H., et al. Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut. 2014;63(5):744-52. Doi: 10.1136/ gutjnl-2012-304066.
- Coskun M. Intestinal epithelium in inflammatory bowel disease. Front Med (Lausanne). 2014;1:24. doi: 10.3389/fmed.2014.00024.
- Michielan A., D'Inca R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015;2015:628157. doi: 10.1155/2015/628157.
- Das P, Goswami P, Das T.K., et al. Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: a new perspective. Virchows Arch. 2012;460(3):261-70. doi: 10.1007/s00428-012-1195-1.
- Fasano A. All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Res. 2020;9:F1000 Faculty Rev-69. doi: 10.12688/f1000research.20510.1.
- John L.J., Fromm M., Schulzke J.D. Epithelial Barriers in Intestinal Inflammation. Antioxid Redox Signal. 2011;15(5):1255-70. Doi: 10.1089/ ars.2011.3892.
- Capaldo C.T., Nusrat A. Claudin switching: Physiological plasticity of the Tight Junction. Semin Cell Dev Biol. 2015;42:22-9. Doi: 10.1016/j. semcdb.2015.04.003.
- Barmeyer C., Schulzke J.D., Fromm M. Claudin-related intestinal diseases. Semin Cell Dev Biol. 2015;42:30-8. Doi: 10.1016/j. semcdb.2015.05.006.
- Onyiah J.C., Colgan S.P Cytokine responses and epithelial function in the intestinal mucosa. Cell Mol Life Sci. 2016;73(22):4203-12. doi: 10.1007/s00018-016-2289-8.
- Kalla R., Ventham N.T., Kennedy N.A., et al. MicroRNAs: new players in IBD. Gut. 2015;64(3):504-17. Doi: 10.1136/ gutjnl-2014-307891.
- Zhou Q., Costinean S., Croce C.M., et al. MicroRNA 29 Targets Nuclear Factor-KB-Repressing Factor and Claudin 1 to Increase Intestinal Permeability. Gastroenterology. 2015;148(1):158-169.e8. doi: 10.1053/j.gastro.2014.09.037.
- Wang H., Chao K., Ng S.C., et al. Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease. Genome Biol. 2016;17:58. doi: 10.1186/s13059-016-0901-8.
- Felwick R.K., Dingley G.J.R., Martinez-Nunez R., et al. MicroRNA23a Overexpression in Crohn's Disease Targets Tumour Necrosis Factor Alpha Inhibitor Protein 3, Increasing Sensitivity to TNF and Modifying the Epithelial Barrier. J Crohns Colitis. 2020;14(3):381-92. doi: 10.1093/ecco-jcc/jjz145.
- Luettig J., Rosenthal R., Barmeyer C., et al. Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers. 2015;3(1-2):e977176. doi: 10.4161/21688370.2014.977176.
- Capaldo C.T., Farkas A.E., Hilgarth R.S. Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell. 2014;25(18):2710-19. doi: 10.1091/mbc.E14-02-0773.
- Van Itallie C.M., Anderson J.M. Architecture of tight junctions and principles of molecular composition. Semin Cell Dev Biol. 2014;36:15-65. doi: 10.1016/j.semcdb.2014.08.011.
- Ivanov A.I. Structure and regulation of intestinal epithelial tight junctions: current concepts and unanswered questions. Adv Exp Med Biol. 2012;763:132-48. doi: 10.1007/978-1-4614-4711-5_6.
- Kucharzik T., Walsh S.V., Chen J., et al. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol. 2001;159(6):2001-9. 1 Doi: 0.1016/S0002-9440(10)63051-9.
- Luissint A.C., Nusrat A., Parkos C.A. JAM-related proteins in mucosal homeostasis and inflammation. Semin Immunopathol. 2014;36(2):211-26. doi: 10.1007/s00281-014-0421-0.
- Vetrano S., Rescigno M., Cera M.R., et al. Unique role of junctional adhesion molecule-A in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology. 2008;135(1):173-84. doi: 10.1053/j.gastro.2008.04.002.
- Furuse M. Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol. 2010;2(1):a002907. doi: 10.1101/cshperspect. a002907.
- Ivanov A.I., Young C., Beste K.D., et al. Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am J Pathol. 2010;176(1):134-45. Doi: 10.2353/ ajpath.2010.090220.
- Tan Y, Guan Y, Sun Y, et al. Correlation of Intestinal Mucosal Healing and Tight Junction Protein Expression in Ulcerative Colitis Patients. Am J Med Sci. 2019;357(3):195-204. doi: 10.1016/j.amjms.2018.11.011.
- Ivanov A.I., Naydenov N.G. Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies. Int Rev Cell Mol Biol. 2013;303:27-99. doi: 10.1016/B978-0-12-407697-6.00002-7.
- Smalley-Freed W.G., Efimov A., Burnett P.E., et al. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 2010;120(6):1824-35. doi: 10.1172/JCI41414.
- Zhang C., Liu L.W., Sun W.J., et al. Expressions of E-cadherin, p120ctn, в-catenin and NF-kB in ulcerative colitis. J Huazhong Univ Sci Technolog Med Sci. 2015;35(3):368-73. Doi: 10.1007/ s11596-015-1439-9.
- Barmeyer C., Fromm M., Schulzke J.D. Active and passive involvement of claudins in the pathophysiology of intestinal inflammatory diseases. Pflugers Arch. 2017;469(1):15-26. doi: 10.1007/s00424-016-1914-6.
- Ivanov A.I., Nusrat A., Parkos C.A. Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell. 2004;15(1):176-88. doi: 10.1091/mbc.e03-05-0319.
- Capaldo C.T, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta. 2009;1788(4):864-71. Doi: 10.1016/j. bbamem.2008.08.027.
- Smyth D, Leung G., Fernando M., et al. Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. PLoS One. 2012;7(6):e38441. Doi: 10.1371/ journal.pone.0038441.
- Lechuga S, Ivanov A.I. Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms. Biochim Biophys Acta Mol Cell Res. 2017;1864(7):1183-94. doi: 10.1016/j.bbamcr.2017.03.007.
- Rodrfguez-Feo J.A., Puerto M., Fernandez-Mena C., et al. A new role for reticulon-4B/NOGO-B in the intestinal epithelial barrier function and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2015;308(12):G981-93. doi: 10.1152/ajpgi.00309.2014.
- Naydenov N.G., Harris G., Brown B., et al. Loss of soluble N-ethylmaleimide-sensitive factor attachment protein a (aSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. J Biol Chem. 2012;287(8):5928-41. Doi: 10.1074/ jbc.M111.278358.
- Naydenov N.G., Brown B., Harris G. A membrane fusion protein aSNAP is a novel regulator of epithelial apical junctions. PLoS One. 2012;7(4):e34320. doi: 10.1371/journal.pone.0034320.
- Baranwal S., Naydenov N.G., Harris G., Nonredundant roles of cytoplasmic в- and y-actin isoforms in regulation of epithelial apical junctions. Mol Biol Cell. 2012;23(18):3542-53. doi: 10.1091/mbc.E12-02-0162.
- Ivanov A.I., Parkos C.A., Nusrat A. Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation. Am J Pathol. 2010;177(2):512-24. doi: 10.2353/ajpath.2010.100168.
- Lechuga S., Baranwal S., Ivanov A.I. Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions. Am J Physiol Gastrointest Liver Physiol. 2015;308(9):G745-56. Doi: 10.1152/ ajpgi.00446.2014.
- Bernadskaya Y.Y, Patel F.B., Hsu H.T., et al. Arp2/3 promotes junction formation and maintenance in the Caenorhabditis elegans intestine by regulating membrane association of apical proteins. Mol Biol Cell. 2011;22(16):2886-99. doi: 10.1091/mbc. E10-10-0862.
- Zhou K., Sumigray K.D., Lechler T The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine. Mol Biol Cell. 2015;26(11):1995-2004. doi: 10.1091/mbc.E14-10-1481.
- Wang D., Naydenov N.G., Feygin A., et al. Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation. Am J Pathol. 2016;186(4):844-58. Doi: 10.1016/j. ajpath.2015.11.023.
- Naydenov N.G., Feygin A., Wang D., et al. Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis. Sci Rep. 2016;6:24161. doi: 10.1038/srep24161.
- Wang F, Graham W.V, Wang Y, et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol. 2005;166(2):409-19. doi: 10.1016/s0002-9440(10)62264-x.
- Blair S.A., Kane S.V, Clayburgh D.R., et al. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest. 2006;86(2):191-201. Doi: 10.1038/ labinvest.3700373.
- Citalan-Madrid A.F., Garcfa-Ponce A., Vargas-Robles H., et al. Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms. Tissue Barriers. 2013;1(5):e26938. doi: 10.4161/tisb.26938.
- Rodgers L.S., Fanning A.S. Regulation of epithelial permeability by the actin cytoskeleton. Cytoskeleton (Hoboken). 2011;68(12):653-60. doi: 10.1002/cm.20547.
- Melendez J., Liu M., Sampson L., et al. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology. 2013;145(4):808-19. doi: 10.1053/j.gastro. 2013.06.021.
- Yang Y, Ma Y, Shi C., et al. Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB. Biochem Biophys Res Commun. 2013;434(4):746-52. doi: 10.1016/j.bbrc.2013.03.122.
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