Familial isolated pituitary adenomas (FIPA): a clinical case of prolactinoma in the same family


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Abstract

Background. The vast majority of pituitary adenomas (PA) are sporadic, and only a small proportion (5%) arise in the framework of hereditary syndromes. More than half of all cases of familial pituitary adenomas are associated with multiple endocrine neoplasia type 1 (MEN-1) and Carney’s complex (CNC). Familial isolated pituitary adenoma (FIPA) is a term used to identify PA in two or more members of the same family in the absence of other endocrine syndromes associated with tumors. The proportion of PA in the framework of FIPA accounts for approximately 2% of the total incidence of pituitary tumors. Description of the clinical case. The article presents a clinical case of the diagnosis of prolactinoma in members of the same family: mother and daughter. Conclusion. PA within the framework of hereditary syndromes account for small proportion of all PA. The evaluation of their clinical and genetic characteristics opens up new possibilities for understanding the pathophysiological processes of their formation. The search for new genes and mutations that can cause the development of hereditary forms of PA is an important and promising area of scientific research.

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About the authors

Inessa B. Zhurtova

Kabardino-Balkarian State University n.a. H.M. Berbekov

Email: zhin07@mail.ru
Faculty of Medicine; Dr. Sci. (Med.), Professor, Department of Faculty Therapy 5 Gorky St., Nalchik 360000, Russian Federation

M. A Elgarova

Kabardino-Balkarian State University n.a. H.M. Berbekov

Faculty of Medicine Nalchik, Russia

L. A Anaeva

Kabardino-Balkarian State University n.a. H.M. Berbekov

Faculty of Medicine Nalchik, Russia

A. Z Getigezheva

Kabardino-Balkarian State University n.a. H.M. Berbekov

Faculty of Medicine Nalchik, Russia

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