Olaparib -modern approach to the treatment of BRCA-associated HER2-negative metastatic breast cancer. Clinical experience
- Authors: Lubennikova E.V1, Zhukova L.G2, Gordeeva O.O1, Drobot N.T.1, Kuznetsov A.V3, Ganshina I.P1
-
Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology
- A.S. Loginov Moscow Clinical Research Center
- Clinical Hospital MEDSI
- Issue: Vol 28, No 7 (2021)
- Pages: 146-152
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313192
- DOI: https://doi.org/10.18565/pharmateca.2021.7.146-150
- ID: 313192
Cite item
Abstract
Keywords
Full Text
About the authors
E. V Lubennikova
N.N. Blokhin National Medical Research Center of Oncology
Email: lubennikova@yandex.ru
Moscow, Russia
L. G Zhukova
A.S. Loginov Moscow Clinical Research CenterMoscow, Russia
O. O Gordeeva
N.N. Blokhin National Medical Research Center of OncologyMoscow, Russia
N. Ts Drobot
N.N. Blokhin National Medical Research Center of OncologyMoscow, Russia
A. V Kuznetsov
Clinical Hospital MEDSIMoscow, Russia
I. P Ganshina
N.N. Blokhin National Medical Research Center of OncologyMoscow, Russia
References
- Gobbini E., Ezzalfani M., Dieras V., et al. Time trends of overall survival among metastatic breast cancer patients in the real-life ESME cohort. Eur J Cancer. 2018;96:17-24. Doi: 10.1016/j. ejca.2018.03.015
- Schmid R, Adams S., Hugo H.S., et al. Atezolizumab and nab-paditaxel in advanced triple-negative breast cancer. N EnglJ Med 2018;3 79(2 2):210S-21. doi: 10.1056/NEJMoa1809615.
- Wooster R.r Weber B.L. Breast and ovarian cancer N Engl J Med. 2003;348(23):2339-47. doi: 10.1056/NEJMra012284.
- Wooster R., Bignell G., Lancaster J., et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378(6559):789-92. doi: 10.1038/378789a0.
- Miki Y, Swensen J., Shattuck-Eidens D., et al. / strong cansusceptibility gene BRCA1. Sci. 1994;266(5182):66-71. Doi: 10.1126/ science. 7545954.
- Jiang Y.Z., Ma D., Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell. 2019;35(3):428-40.e5. doi: 10.1016/j.ccell.2019.02.001. strand break repair-independent role for В RCA 2 in blocking stalled replication fork degradation by MRE11. Cell. 2011;145(4):529-42. doi: 10.1016/j.cell. 2011.03.041.
- Schlacher K., Christ N., Siaud N., et at Double mutation and HER2-negative metastatic breast trends of overall survival among metastatic breast cancer patients in the real-life ESME cohort Eur J Cancer. 2018;96:17-24. Doi: 10.1016/j. ejca.2018.03.015
- Ramus S.J., Gayther S.A. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol. 2009;3(2):138-50. Doi: 10.1016/j. molonc.2009.02.001.
- Robson M., Im S.A., Senkus E., et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N EnglJ Med. 2017;3 77(6/523-33. doi: 10.1056/NEJMoa1706450.
- Tung N.M., Im S.A., Senkus-Konefka E., et al. Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer (OlympiAD): Efficacy in patients with visceral metastases. J Clin Oncol. 2018;36(Suppl. 15/1052-52. doi: 10.1200/JC0.2018.36.15_ suppl. 1052.
- Robson M.E., Tung N., Conte P, et al. OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA cancer. Ann Oncol. 2019;30(4):558-66. doi: 10.1093/annonc/mdz012.
- Robson M., Ruddy K.J., Im S.A., et al. 4542 -OlympiAD: Health-related quality of life (HRQoL) in pa dents with HER 2- negative metastatic breast ca ncer (mBC) and a germline BRCA mutation (gBRCAm) receiving olaparib monotherapy vs standard singleagent chemotherapy treatment of physician's choice (TPC). Ann Oncol. 2017;28(Suppl. 5/S74-108. doi: 10.1093/annonc/mdx365.
- Gelmon K.A., Walker G.P, Fisher G.V., McCutcheon S. C. LUCY: A phase 11 lb, real-world study of olaparib in HER2-negative metastatic breast cancer patients with a BRCA mutation. Ann Oncol. 2018;29(Suppl. 8/VIII120. doi: 10.1093/annonc/mdy272.355.
- Richards S., Aziz N., Bale S., et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17(5):405-24. doi: 10.1038/gim.2015.30.