Review of modern methods of prevention and correction of post-acne symptom complex


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. According to the World Health Organization for 2020, 90% of adolescents, 55% of adults under the age of 25 and 17% after 25 years of age suffer from acne of varying severity. Persistent post-inflammatory erythema and dyschromias, cicatricial skin deformities occur in about a third of patients as a result of the resolution of rashes or during treatment. The formation of the post-acne symptom complex is caused by long-term persistent inflammation during healing; however, it is often associated with the use of aggressive invasive protocols for correcting the underlying disease (peelings, dermabrasion, planar high-intensity laser therapy technologies), and also occurs as a result of self-treatment (regular excoriation). Located on the face and other open areas of the body, fibrous and pigmentary disorders have a significant impact on the patient’s psychological state, and can complicate the search for a successful job and cause suicidal thoughts. Regular review and scientific substantiation of effective preventive and therapeutic methods for correcting post-inflammatory pigmentation disorders and acne scars is one of the leading modern trends in dermatocosmetology. Objective. Analysis of definitive studies with high methodological quality on the use of various methods of correction and prevention of post-acne symptom complex. Results. Clinical effects and probable mechanisms of action of methods of treatment and prevention of the development of post-acne symptom complex are discussed. It was found that the most frequently used methods for correction are high-intensity laser therapy (28%), intralesional injections (18%), topical agents (23%) and complex therapy programs (33%), which have significant clinical effects. Conclusion. Based on modern ideas about the pathogenesis of the post-acne symptom complex, it is advisable to search for new methods of therapy aimed at preventing its formation and correction. In addition to regularly summarizing and analyzing existing evidence-based studies, it is necessary to perform new high-quality randomized controlled clinical trials to study and compare the effectiveness of preventive treatment and methods of therapeutic correction. Taking into account the results obtained, it can be concluded that it is necessary to prescribe depigmenting, anti-inflammatory and anti-scarring agents both for prevention at the earliest stages of post-acne formation and for the correction of already existing aesthetic defects.

Full Text

Restricted Access

About the authors

Inga G. Kurganskaya

S.M. Kirov Military Medical Academy

Email: manga-85@mail.ru
Cand. Sci. (Med.)., Lecturer at the Department of Skin and Venereal Diseases St. Petersburg, Russia

A. V Patrushev

S.M. Kirov Military Medical Academy

St. Petersburg, Russia

N. A Shanina

S.M. Kirov Military Medical Academy

St. Petersburg, Russia

References

  1. Острецова М. Н. Современный взгляд на проблему этиопатогенеза и классификации рубцовых проявлений симптомокомплекса постакне. Российский журнал кожных и венерических болезней. 2017;20:167-73.
  2. Tosti A. Pia De Padova M., Fabbrocini G., et al. Acne Scars: Classification and Treatment (Second Edition). CRC Press, 2019. 191 р.
  3. Fu C, Chen J., Lu J., et al. Roles of inflammation factors in melanogenesis (Review). Molecular medicine reports. 2020;21(3):1421-30. doi: 10.3892/mmr.2020.10950.
  4. Rippa A.L., Kalabusheva E.P., Vorotelyak E.A. Regeneration of Dermis: Scarring and Cells Involved. Cells. 2019;8(6):607. Doi: 10.3390/ cells8060607.
  5. D'Mello S.A., Finlay G.J., Baguley B.C., et al. Signaling Pathways in Melanogenesis. Int J Mol Sci. 2016;17(7):1144. doi: 10.3390/ijms17071144.
  6. Круглова Л.С., Иконникова Е.В. Гиперпигментация кожи: современный взгляд на методы коррекции. Российский журнал кожных и венерических болезней.2017;20(4):248-51.
  7. Connolly D., Vu H.L., Mariwalla K., et al. Acne scarring - pathogenesis, evaluation, and treatment options. J Clin Aesth Dermatol. 2017; 10(9):12-23.
  8. Tan J., Kang S., Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the Unites States. J Drugs Dermatol. 2017;16(2):97-102. Doi: 10.12688/ f1000research.23737.1.
  9. Wu Y, Wang B., Li Y.H., et al. Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibility to keloids in the Chinese population. Genet Mol Res. 2012;11(2):1701-11. doi: 10.4238/2012. June.29.2.
  10. Porter J.E., Camacho M., Viteri M.I., et al. Pilot study for the evaluation and adaptation of a Four Item-Acne-Scar Risk Assessment Tool (4-ASRAT): a resource to estimate the risk of acne-induced scars. F1000Res. 2020;9:651. Doi: 10.12688/ f1000research.23 737.1.
  11. Ковалёва Л.Н. Клинико-морфологические параллели у пациентов с рубцовой патологией кожи. Дерматовенерология. Косметология. Сексопатология.2016;1:108-17.
  12. Van Putte L., De Schrijver S., Moortgat P., et al. The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review. Scars Burn Heal. 2016;2:2059513 116676828. doi: 10.1177/2059513116676828.
  13. Вавилова А.А., Губанова Е.И., Гладько В.В. Гликационный стресс и фотостарение кожи. Российский журнал кожных и венерических болезней. 2017;20(4):243-48.
  14. Мантурова Н.Е., Талыбова А.М., Круглова Л.С. и др. Профилактика и лечение атрофических рубцов постакне. Клиническая дерматология и венерология. 2018;17(5):85-100
  15. Круглова, Л. С., Колчева П. А., Корчажкина Н. Б. Обзор современных методов коррекции рубцов постакне. Вестник новых медицинских технологий. 2018;25(4):155-63
  16. Карабут М.М., Гладкова Н.Д., Фельдштейн Ф.И. Фракционный лазерный фототермолиз в лечении кожных дефектов: возможности и эффективность (обзор). Современные технологии в медицине. 2016;8(2):98-06
  17. Kravvas G., Al-Niaimi F. A systematic review of treatments for acne scarring. Part 1: Non-energy-based techniques. Scars Burn Heal. 2017;30:3. doi: 10.1177/2059513117695312
  18. Kravvas G., Al-Niaimi F. A systematic review of treatments for acne scarring. Part 2: Energy-based techniques. Scars Burn Heal. 2018;16:4. doi: 10.1177/2059513118793420
  19. Dreno B., Bissonnette R., Gagne-Henley A., et al. Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2,5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison. Am J Clin Dermatol. 2018;19(2):275-86. doi: 10.1007/s40257-018-0352-y
  20. Behrangi E., Goodarzi A., Masoumeh R., et al. A review of scar treatment related to acne and burn. JCR. 2020;7(4):714-22. Doi: 10.31838/ jcr.07.04.133.
  21. Kim S.H., Lee S.J., Lee J.W., et al. Clinical trial to evaluate the efficacy of botulinum toxin type A injection for reducing scars in patients with forehead laceration: A double-blinded, randomized controlled study. Medicine (Baltimore). 2019;98(34):e16952. Doi: 10.1097/ MD.0000000000016952.
  22. Alhetheli G., Elneam A.I.A., Alsenaid A., et al. Vitamin D Levels in Patients with and without Acne and Its Relation to Acne Severity: A Case-Control Study. Clin Cosmet Investig Dermatol.2020;13:759-65. doi: 10.2147/CCID. S271500.
  23. Thiyagarasaiyar K., Goh B.H., Jeon Y.J., et al. Algae Metabolites in Cosmeceutical: An Overview of Current Applications and Challenges. Mar Drugs. 2020;18(6):323-45. Doi: 10.3390/ md18060323.
  24. DePhillipo N.N., Aman Z.S., Kennedy M.I., Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop. J Sports Med. 2018;6(10):2325967118804544. doi: 10.1177/2325967118804544.
  25. Meseci E., Kayatas S., Api M., et al. Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention - a randomized controlled trial. Ginekol Pol. 2017;88(11):591-98. Doi: 10.5603/ GPa2017.0107.
  26. Zhang Q., Tu Y., Gu H., et al. A cream of herbal mixture to improve melasma. J Cosmet Dermatol. 2019;18(6):1721-28. Doi: 10.1111/ jocd.12938.
  27. Hollinger J.C., Angra K., Halder R.M. Are Natural Ingredients Effective in the Management of Hyperpigmentation? A Systematic Review. J Clin Aesthet Dermatol. 2018;11(2):28-37.
  28. Ud-Din S., Foden P., Mazhari M., et al. A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin. J Invest Dermatol. 2019;139(8):1680-90.e16. doi: 10.1016/j.jid.2019.01.030.6.
  29. Ruan Q.Z., Chen A.D., Tran B.N.N., et al. Integrative Medicine in Plastic Surgery: A Systematic Review of Our Literature. Ann Plast Surg.2019;82(4):459-doi: 10.1097/SAP0000000000001676.
  30. Prager W., Gauglitz G.G. Effectiveness and Safety of an Overnight Patch Containing Allium cepa Extract and Allantoin for Post-Dermatologic Surgery Scars. Aesthetic Plast Surg. 2018;42(4):1144-50. doi: 10.1007/s00266-018-1172-4.
  31. Grek C.L., Montgomery J., Sharma M., et al. A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring. J Invest Dermatol. 2017;137(3):620-30. doi: 10.1016/j.jid.2016.11.006.
  32. Alven S., Aderibigbe B.A. Chitosan and Cellulose-Based Hydrogels for Wound Management. Int J Mol Sci.2020;21(24):9656. Doi: 10.3390/ ijms21249656.
  33. Marasca C., Ruggiero A., Marasca D., et al. Skin Needling in Combination with Antimicrobial Peptides for the Treatment of Keloids: A Novel Perspective Proposal and Approach for Skin Scars. Dermatology. 2020;236(6):601-2. doi: 10.1159/000507927.
  34. Иконникова Е. В., Стенько А. Г. Гиперпигментация: современный взгляд на этиологию и методы коррекции. Тенденции развития науки и обра зования. 2017;23(3):6-12.
  35. Przekora A. A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro? Cells. 2020;6;9(7):1622. Doi: 10.3390/ cells9071622.
  36. Mirastschijski U., Schwab I., Coger V., et al. Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study. Sci Rep. 2020;10(1):2581. doi: 10.1038/s41598-020-59394-5.
  37. Poinas A., Perrot P., Lorant J., et al. CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a splitthickness skin graft donor site versus a traditional dressing: a randomized controlled trial. Trials. 2019;20(1):612. doi: 10.1186/s13063-019-3718-4.
  38. Zhang C., Wang T., Zhang L., et al. Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring. Stem Cell Res Ther. 2021;12(1):23. doi: 10.1186/s13287- 020-02061-3.
  39. Szelest M., Walczak K., Plech T. A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes. Int J Mol Sci. 2021;22(3):1104. doi: 10.3390/ijms22031104.
  40. El Ayadi A., Prasai A., Wang Y, et al. ß-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. J Invest Dermatol. 2018;138(7):1645-55. Doi: 10.1016/j. jid.2018.01.037.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies