Modern concepts of autophagy in the concept of premature aging


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Abstract

It has long been recognized that the rate of skin aging is determined by internal and external factors, but only recent advances in skin gerontology have helped to analyze the molecular and cellular processes that underlie skin aging. Some of the aging processes are triggered or enhanced by the presence of damaged molecules and organelles within cells, and their turnover is partly controlled by autophagy. In this article, we look at the contribution of autophagy to the control of premature skin aging. We propose the concept that aging is driven by changes in three categories of cells with different dependencies on autophagy. Modern protocols for the treatment of acne, rosacea and premature aging should be based on the latest scientific pathogenetic data and include injection and hardware methods. The experimental drug tested by us is definitely the procedure of choice in preparation for invasive techniques and as a tool for activating autophagy in cosmetic patients.

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About the authors

Elena V. Svechnikova

Polyclinic № 1 of the Administrative Department of the President of the Russian Federation; Novosibirsk State Medical University

Email: elene-elene@bk.ru
Dr. Sci .(Med.), Head of the Department of Dermatovenereology and Cosmetology; Professor at the Department of Dermatovenereology and Cosmetology Moscow, Russia; Novosibirsk, Russia

V. V Ashapkin

Lomonosov Moscow State University

Research Institute of Physical and Chemical Biology n.a. A.N. Belozersky Moscow, Russia

M. A Morzhanaeva

Novosibirsk State Medical University

Novosibirsk, Russia

A. G Dzukaev

Skin Expert Clinic

Moscow, Russia

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