Systematic review and meta-analysis: predictors of psoriatic arthritis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Psoriasis is a chronic systemic immune-inflammatory disease that affects not only the skin, but also the musculoskeletal system. According to epidemiological and clinical studies, every fourth patient with psoriasis develops psoriatic arthritis. Early diagnosis and early initiation of therapy allows to prevent the development of severe forms and disability. Identification of early predictors of psoriatic arthritis and referral of such patients for rheumatological examination may help to solve this problem. Methods. The existing literature was searched in the PubMed (MEDLINE), EMBASE and Google Scholar databases for 10 years up to 02/20/2021. The search for current registered trials was carried out in the clinical trial registries of the United States (Clinicaltrials. gov), China (Chinese Clinical Trial Registry) and the WHO International clinical trial registry platform. Statistical analyzes were prepared in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) using Statistic SPSS 26.0 (US-manufactured). Meta-analysis was prepared using RevMan 5 software. Results. We identified 342 articles published up to February 20, 2021. After further analysis, irrelevant articles were excluded. A total of 35 articles were included in the review and analysis. psoriatic arthritis predictors include enthesitis, nail lesions, uveitis, and axial lesions. In addition, there are biomarkers for psoriatic arthritis. According to meta-analysis, a statistically significant increase in the risks of developing psoriatic arthritis by 1.52 times (95% C11.22-1.88) was noted in the presence of damage to the nail apparatus. In addition, not only the risks of developing psoriatic arthritis but also the chances of developing psoriatic arthritis increased with statistical significance by 2.76 times (95% CI: 1.94-3.92). Conclusion. Psoriasis and psoriatic arthritis are multifactorial diseases with sharply reduced quality of life of patients, the possible development of severe forms and disability. Therefore, early diagnosis of such conditions is very important. Nail damage can be considered as predictors of psoriatic arthritis, so it is very important for dermatologists to evaluate not only smooth skin. Further research is needed to better understand this issue.

Full Text

Restricted Access

About the authors

Natalia O. Pereverzina

Central State Medical Academy of the Administrative Department of the President of th Russian Federation

Email: natalia.pereverzina@gmail.com
Moscow, Russia

L. S Kruglova

Central State Medical Academy of the Administrative Department of the President of th Russian Federation

Moscow, Russia

T. V Korotaeva

V.A. Nasonova Research Institute of Rheumatology

Moscow, Russia

A. M Lila

V.A. Nasonova Research Institute of Rheumatology

Moscow, Russia

References

  1. Boehncke W.H., Schn M.P. Psoriasis. Lancet. 2015;386(9997):983-94. Doi: 10.1016/ S0140-6736(14)61909-7.
  2. Chimenti M.S., Caso F., Alivernini S., et al. Amplifying the concept of psoriatic arthritis: The role of autoimmunity in systemic psoriatic disease. Autoimmun Rev. 2019;18(6):565-75. doi: 10.1016/j.autrev.2018.11.007.
  3. Veale D.J., Fearon U. The pathogenesis of psoriatic arthritis. Lancet. 2018;391(10136):2273-84. doi: 10.1016/S0140-6736(18)30830-4.
  4. Кубанов А.А, Богданова Е.В. Организация и результаты оказания медицинской помощи по профилю «дерматовенерология» в Российской Федерации. Итоги 2018 г. Вестник дерматологии и венерологии. 2019.95(4):8-13.
  5. Alinaghi F., Calov M., Kristensen L.E., et al. Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies. J Am Acad Dermatol. 2019;80(1):251-65.e19. doi: 10.1016/j.jaad.2018.06.027.
  6. Коротаева Т.В., Корсакова Ю.Л., Логинова Е.Ю. и др. Псориатический артрит. Клинические рекомендации по диагностике и лечению. Современная ревматология. 2018;12(2):22-
  7. Tillett W, Charlton R., Nightingale A., et al.Interval between onset of psoriasis and psoriatic arthritis comparing the UK Clinical Practice Research Datalink with a hospital-based cohort. Rheumatol. (Oxford). 2017;56(12):2109-13. doi: 10.1093/rheumatology/kex323.
  8. Haroon M, Gallagher P., FitzGerald O. Diagnostic delay of more than 6 months contributes to poor radiographic and functional outcome in psoriatic arthritis. Ann Rheum Dis. 2015;74(6):1045-50. doi: 10.1136/annrheumdis-2013-204858.
  9. Burgers L.E., Raza K., van der Helm-van Mil A.H. Window of opportunity in rheumatoid arthritis - definitions and supporting evidence: from old to new perspectives. RMD Open. 2019;5(1):e000870. Doi: 0.1136/ rmdopen-2018-000870.
  10. van Steenbergen H.W., da Silva J.A.P, Huizinga T.W.J., et al. Preventing progression from arthralgia to arthritis: targeting the right patients. Nat Rev Rheumatol. 2018;14(1):32-41. Doi: 10.1038/ nrrheum.2017.185.
  11. McGonagle D., Tan A.L., Benjamin M. The biomechanical link between skin and joint disease in psoriasis and psoriatic arthritis: what every dermatologist needs to know. Ann Rheum Dis. 2008;67(1):1-4. Doi: 10.1136/ ard.2007.080952.
  12. Tillett W, Jadon D., Shaddick G., et al. Smoking and delay to diagnosis are associated with poorer functional outcome in psoriatic arthritis. Ann Rheum Dis. 2013;72(8):1358-61. doi: 10.1136/annrheumdis-2012-202608.
  13. Lai T.L., Pang H.T., Cheuk Y.Y., et al. Psoriatic nail involvement and its relationship with distal interphalangeal joint disease. Clin Rheumatol. 2016;35(8):2031-37. doi: 10.1007/s10067-016-3319-5.
  14. Taylor W, Gladman D., Helliwell P., et al. CASPAR Study Group. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthr Rheum. 2006;54(8):2665-73. Doi: 10.1002/ art.21972.
  15. Raposo I., Torres T. Nail psoriasis as a predictor of the development of psoriatic arthritis. Actas Dermosifiliogr. 2015;106(6):452-7. English, Spanish. doi: 10.1016/j.ad.2015.02.005.
  16. van Muijen M.E., van Hal T.W., Groenewoud H.M.M., et al. The Skin May Clear But the Arthritis Won't Disappear: Focusing on Concomitant and New-Onset Psoriatic Arthritis in a Daily Practice Cohort of Psoriasis Patients on Biologic Therapy. Psoriasis (Auckl). 2020;10:29-37. doi: 10.2147/PTT.S270619.
  17. Chaiyabutr C., Ungprasert P., Silpa-Archa N., et al. Psoriasis and Risk of Uveitis: A Systematic Review and Meta-Analysis. Biomed Res Int. 2020;2020:9308341. doi: 10.1155/2020/9308341.
  18. El-Asrar A.M., Struyf S., Kangave D., et al. Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis. Clin Immunol. 2011;139(2):177-84. doi: 10.1016/j.clim.2011.01.014.
  19. Ooi K.G., Galatowicz G., Calder V.L., et al. Cytokines and chemokines in uveitis: is there a correlation with clinical phenotype? Clin Med Res. 2006;4(4):294-309. doi: 10.3121/cmr.4.4.294.
  20. Queiro R., Morante I., Cabezas I. et al. HLA-B27 and psoriatic disease: a modern view of an old relationship. Rheumatol (Oxford). 201 6;55(2):22 1-29. Doi: 1 0.1 093/ rheumatology/kev296.
  21. Wakefield D., Yates W., Amjadi S., et al. HLA-B27 Anterior Uveitis: Immunology and Immunopathology. Ocul Immunol Inflamm 2016;24(4):450-9. doi: 10.3109/09273948. 2016.1158283.
  22. Gladman D.D. Axial disease in psoriatic arthritis. Curr Rheumatol Rep. 2007;9(6):455-60. doi: 10.1007/s11926-007-0074-2.
  23. Menter A, Korman NJ, et al.: American Academy of Dermatology Work Group, Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J Am Acad Dermatol. 2011;65(1):137-74. doi: 10.1016/j.jaad.2010.11.055.
  24. Chandran V., Barrett J., Schentag C.T., et al. Axial psoriatic arthritis: update on a longterm prospective study. J Rheumatol. 2009;36(12):2744-50. doi: 10.3899/jrheum.090412.
  25. Jadon D.R., Sengupta R., Nightingale A., et al. Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis. Ann Rheum Dis. 2017;76(4):701-7. Doi: 10.1136/ annrheumdis-2016-209853.
  26. Ritchlin C.T., Colbert R.A., Gladman D.D. Psoriatic Arthritis. N Engl J Med. 2017 9;376(10):957-970. doi: 10.1056/NEJMra1505557. Erratum in: N Engl J Med. 2017;376(21):2097.
  27. Queiro R., Belzunegui J., Gonzalez C., et al. Clinically asymptomatic axial disease in psoriatic spondyloarthropathy. A retrospective study. Clin Rheumatol. 2002;21(1):10-3. Doi: 10.1007/ s100670200003.
  28. Haroon M., Winchester R., Giles J.T., et al. Clinical and genetic associations of radiographic sacroiliitis and its different patterns in psoriatic arthritis. Clin Exp Rheumatol. 2017;35(2):270-6.
  29. Chandran V., Tolusso D.C., Cook R.J., et al. Risk factors for axial inflammatory arthritis in patients with psoriatic arthritis. J Rheumatol. 201 0;37(4):809-1 5. Doi: 10.3899/ jrheum.091059.
  30. Feld J., Chandran Varoon N., et al. Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison. Nat Rev Rheumatol. 2018;14(6):363-71. doi: 10.1038/s41584-018-0006-8.
  31. Gladman D.D., Thavaneswaran A., Chandran V., et al. Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease? Ann Rheum Dis. 2011;70(12):2152-54 doi: 10.1136/ard.2011.150938.
  32. Круглова Л.С., Львов А.Н., Пушкина А.В. Риски и предикторы развития псориатического артрита при псориазе и вопросы раннего назначения генно-инженерных биологических препаратов. Клиническая дерматология и венерология. 2020;19(3)
  33. Stuart PE., Nair R.P, Tsoi L.C., et al. Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. Am J Hum Genet. 2015;97(6):816-36. Doi: 10.1016/j. ajhg.2015.10.019.
  34. Abji F., Pollock R.A., Liang K., et al. Brief Report: CXCL10 Is a Possible Biomarker for the Development of Psoriatic Arthritis Among Patients With Psoriasis. Arthr Rheumatol. 2016;68(12):2911-16. doi: 10.1002/ art.39800.
  35. Pollock R.A., Abji F., Liang K., et al. Gene expression differences between psoriasis patients with and without inflammatory arthritis. J. Invest. Dermatol. 2015;135(2):620-23. Doi: 10.1038/ jid.2014.414.
  36. Cretu D., Gao L., Liang K., et al. Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers. Arthr Care Res. (Hoboken). 2018;70(3):454-61. doi: 10.1002/acr.23298.
  37. Frasca L., Palazzo R., Chimenti M.S., et al. Anti-LL37 Antibodies Are Present in Psoriatic Arthritis (PsA) Patients: New Biomarkers in PsA. Front Immunol. 2018;9:1936. Doi: 10.3389/ fimmu.2018.01936.
  38. Yuan Y., Qiu J., Lin Z.T., et al. Identification of Novel Autoantibodies Associated With Psoriatic Arthritis. Arthr Rheumatol. 2019;71(6):941-51.
  39. Dolcino M., Lunardi C., Ottria A., et al. Crossreactive autoantibodies directed against cutaneous and joint antigens are present in psoriatic arthritis. PLoS One. 2014;9(12):e115424. Doi: 10.1371/ journal.pone.0115424.
  40. Chimenti M.S., Triggianese P., Nuccetelli M., et al. Auto-reactions, autoimmunity and psoriatic arthritis. Autoimmun Rev. 2015;14(12):1142-6. doi: 10.1016/j.autrev.2015.08.003.
  41. Fitzgerald O., Ritchlin C.T., Mease P.J. Biomarkers of radiographic progression in psoriatic arthritis: a report from the GRAPPA 2011 annual meeting. J Rheumatol. 2012;39(11):2189-92. doi: 10.3899/jrheum.120820.
  42. Mc Ardle A., Flatley B., Pennington S.R., et al. Early biomarkers of joint damage in rheumatoid and psoriatic arthritis. Arthr Res Ther. 2015;17(1):141. doi: 10.1186/s13075-015-0652-z.
  43. Cretu D, Prassas I., Saraon P, et al. Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry. Clin Proteom. 2014;11(1):27. doi: 10.1186/15590275-11-27.
  44. Cretu D, Liang K., Saraon P., et al. Quantitative tandem mass-spectrometry of skin tissue reveals putative psoriatic arthritis biomarkers. Clin Proteom. 2015;12(1):1. doi: 10.1186/15590275-12-1.
  45. Bronckers I.M.G.J., Bruins F.M., van Geel M.J., et al. Nail Involvement as a Predictor of Disease Severity in Paediatric Psoriasis: Follow-up Data from the Dutch ChildCAPTURE Registry. Acta Derm Venereol. 2019;99(2):152-57. doi: 10.2340/00015555-3036.
  46. Choi J.W., Kim B.R., Seo E, et al. Could Psoriatic Arthritis Be Easily Diagnosed from Current Suspicious Physical Findings in the Dermatology Clinic? Ann Dermatol. 2017;29(1):48-54. doi: 10.5021/ad.2017.29.1.48.
  47. Diani M., Perego S., Sansoni V., et al. Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.Int JMol Sci. 2019;20(22):5617. doi: 10.3390/ijms20225617.
  48. Eder L., Law T., Chandran V., et al. Association between environmental factors and onset of psoriatic arthritis in patients with psoriasis. Arthr Care Res. (Hoboken). 2011;63(8):1091-97. doi: 10.1002/acr.20496.
  49. Ficco H.M., Citera G., Cocco J.A. Prevalence of psoriatic arthritis in psoriasis patients according to newer classification criteria. Clin Rheumatol. 2014;33(10):1489-93. doi: 10.1007/s10067-014-2651-x.
  50. Gladman D.D., Chandran V. Observational cohort studies: lessons learnt from the University of Toronto Psoriatic Arthritis Program. Rheumatol. (Oxford). 2011;50(1):25-31. Doi: 10.1093/ rheumatology/keq262.
  51. Lai T.L., Pang H.T., Cheuk Y.Y., et al. Psoriatic nail involvement and its relationship with distal interphalangeal joint disease. Clin Rheumatol. 2016;35(8):2031-7. doi: 10.1007/s10067-016-3319-5.
  52. Love T.J., Gudjonsson J.E., Valdimarsson H., et al. Psoriatic arthritis and onycholysis -- results from the cross-sectional Reykjavik psoriatic arthritis study. J Rheumatol. 2012;39(7):1441-44. doi: 10.3899/jrheum.111298.
  53. Langenbruch A., Radtke M.A., Krensel M., et al. Nail involvement as a predictor of concomitant psoriatic arthritis in patients with psoriasis. Br J Dermatol. 2014;171(5):1123-28. doi: 10.1111/bjd.13272.
  54. Maejima H., Taniguchi T., Watarai A., et al. Evaluation of nail disease in psoriatic arthritis by using a modified nail psoriasis severity score index.Int J Dermatol. 2010;49(8):901-6. doi: 10.1111/j.1365-4632.2009.04452.x.
  55. Yan D., Ahn R., Leslie S., et al. Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis. Dermatol Ther (Heidelb). 2018;8(4):593-604. Doi: 10.1007/ s13555-018-0266-x.
  56. Yang Q., Qu L., Tian H., et al. Prevalence and characteristics of psoriatic arthritis in Chinese patients with psoriasis. J Eur Acad Dermatol Venereol. 2011;25(12):1409-14. doi: 10.1111/j.1468-3083.2011.03985.x.
  57. Zargari O., Leyli E.K., Azimi S.Z. Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran. Autoimmun. Dis. 2018;2018:4608490. doi: 10.1155/2018/4608490.
  58. Zenke Y., Ohara Y., Kobayashi D., et al. Nail findings in patients with psoriatic arthritis: A crosssectional study with special reference to transverse grooves. J Am Acad Dermatol. 2017;77(5):863-67. doi: 10.1016/j.jaad.2017.04.001.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies