The key role of an emollient with an active antipruritic component in the strategy for improving the quality of life of patients of the older age group with itching against the background of xerosis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. In patients of the older age group, physiological xerosis of the skin is caused by structural and qualitative changes in the epidermis and dermis, and “fragility" - by decrease in the activity of the immune system in the epidermis. Skin xerosis can cause itching, which negatively affects quality of life (QoL). Objective. Evaluation of the effectiveness of Neotanin Comfort Plus cream in elderly patients with skin xerosis and itching. Methods. An open non-comparative study with 2-week follow-up period was carried out. 40 patients aged 60 to 74 years with skin xerosis and itching were included in the study. For two weeks, all patients used Neotanin Comfort Plus cream as a skin care product 1-2 times a day, and also during the day as needed. Results. As a result of the use of Neotanin Comfort Plus cream, the corneometry indicator increased by 16,6% (localization on the back) and by 12.3% (shin area), the indicator of transepidermal water loss decreased by 13.8% and 10.1%, respectively. The MAS indicator (itching) decreased by 85.1%, the total QoL index improved by 77.6%. All patients noted excellent or good organoleptic properties of the cream and the comfort of its use. Thus, 97.5% of patients rated the comfort/convenience during application as excellent or good, 95% of patients noted an excellent/good feeling after applying the cream, 95% - excellent absorption of the cream. Conclusion. Neotanin Comfort Plus cream can be recommended for patients with skin itching against the background of xerosis.

Full Text

Restricted Access

About the authors

Larisa S. Kruglova

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: kruglovals@mail.ru
Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology Moscow, Russia

E. A Shatokhina

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Moscow, Russia

References

  1. United Nations. World Population Ageing. URL https://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2015_Report.pdf (accessed 11 April 2018).
  2. Fabbrocini G, Rossi A.B., Thouvenin M.-D., et. al. Fragility of epidermis: acne and post-procedure lesional skin. J Eur Acad Dermatol Venereol. 2017;31(6):3-18. doi: 10.1111/jdv.14410.
  3. Круглова Л.С, Райцева С.С., Матусевич С.Л. Группа конституциональных эстетических рисков в инъекционной косметологии: паци енты с синдромом «чувствительной кожи». Пластическая хирургия и эстетическая медицина. 2019;3:38-42
  4. Blume-Peytavi U. Response to ‘The concept of fragile skin: a case of dis- ease mongering in dermatology?' J Eur Acad Dermatol Venereol. 2017;31:e282-83. doi: 10.1111/jdv.14047.
  5. Круглова Л.С., Львов А.Н., Аравийская Е.Р и др. Практические вопросы применения эмолентов в ведении пациентов с ксерозом кожи: резолюция совета экспертов России, Казахстана и Республики Беларусь. Кремлевская медицина. Клиническая вестник. 2021;4:103-15.
  6. Haftek M., Coutanceau C., Taieb C. Epidemiology of "fragile skin": results from a survey of different skin types. Clin Cosmet Investig Dermatol. 2013;6:289-94. doi: 10.2147/CCID.S55223.
  7. Berger T.G., Steinhoff M. Pruritus in elderly patients - eruptions of senescence. Semin Cutan Med Surg. 2011;30:113-17. Doi: 10.1016/j. sder.2011.04.002.
  8. Круглова Л.С., Понич Е.С., Левшин Р.Н. Барьерная функция кожи: основные причины нарушений и методы коррекции. ЮжноУральский медицинский журнал. 2015;2:37-44.
  9. Farage M.A., Miller K.W., Berardesca E., Maibach H.I. Clinical implications of aging skin: cutaneous disorders in the elderly. Am J Clin Dermatol. 2009;10:73-86. doi: 10.2165/00128071200910020-00001.
  10. Farage M.A., Miller K.W., Elsner P, Maibach H.I. Characteristics of the aging skin. Adv Wound Care (New Rochelle). 2013;2:5-10. Doi: 10.1089/ wound.2011.0356.
  11. Cesari M, Incalzi R.A., Zamboni V., Pahor M. Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int. 2011;11:133-42. doi: 10.1111/j.1447-0594.2010.00668.x.
  12. Jackson S.M., Williams M.L., Feingold K.R., Elias P.M. Pathobiology of the stratum corneum. West J Med. 1993;158:279-85.
  13. Farage M.A., Miller K.W., Elsner P, Maibach H.I. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol. 2007;26:343-57. doi: 10.1080/15569520701622951.
  14. Berger T.G., Shive M., Harper G.M. Pruritus in the older patient: a clinical review. JAMA. 2013;310:2443-50. Doi: 10.1001/ jama.2013.282023.
  15. Blume-Peytavi U., Kottner J., Sterry W., et al. Age-associated skin conditions and diseases: current perspectives and future options. Gerontol. 2016;56(2):S230-42. doi: 10.1093/geront/ gnw003.
  16. Круглова Л.С., Шатохина Е.А. Синий спектр света: воздействие на кожу и фотопротекция. Медицинский алфавит. Дерматология. 2022;1:12-8
  17. Rees J.L. The genetics of sun sensitivity in humans. Am J Hum Genet. 2004;75:739-51. doi: 10.1086/425285.
  18. Haddad M.M., Xu W., Medrano E.E. Aging in epidermal melanocytes: cell cycle genes and melanins. J Investig Dermatol Symp Proc. 1998;3:36-40.
  19. Puizina-Ivic N. Skin aging. Acta Dermatovenerol. Alp. Pannonica Adriat. 2008;17:47-54.
  20. Rinnerthaler M., Bischof J., Streubel M.K., et al. Oxidative stress in aging human skin. Biomolecul. 2015;5:545-89. doi: 10.3390/biom5020545.
  21. Ortiz A., Grando S.A. Smoking and the skin.Int J Dermatol. 2012;51:250-62. doi: 10.1111/j.1365-4632.2011.05205.x.
  22. Sorensen L.T. Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review. Ann Surg. 2012;255:1069-79. Doi: 10.1097/ SLA.0b013e31824f632d.
  23. Nuaimi Y., Sherratt M.J., Griffiths C.E.M. Skin health in older age. Maturitas. 2014;79:256-64. doi: 10.1016/j.maturitas.2014.08.005.
  24. Humbert P., Dreno B., Krutmann J., et al. Recommendations for managing cutaneous disorders associated with advancing age. Clin Interv Aging. 2016;11:141-48. Doi: 10.2147/ CIA.S96232.
  25. Круглова Л.С., Панина А.Н., Стрелкович Т.И. Современное представление о трофических язвах венозного генеза. Российский журнал кожных и венерических болезней. 2014;1:21-
  26. Круглова Л.С., Переверзина Н.О., Коваленко Ю.А. Противозудная терапия как основная составляющая повышения качества жизни пациентов с дерматозами. Медицинский алфавит. 2020;6(420)1:6-11
  27. Коваленко Ю. А., Круглова Л.С., Шатохина Е.А. Современные представления о механизмах развития и фармакотерапии кожного зуда. Клиническая дерматология и венерология. 2021;20(1):90-6
  28. Stalder J.F., Tennstedt D., Deleuran M., et al. Fragility of epidermis and its consequence in dermatology. J Eur Acad Dermatol Venereol. 2014;28(4):1-18. doi: 10.1111/jdv.12509.
  29. Liao Y.H., Chen K.H., Tseng M.P, Sun C.C. Pattern of skin diseases in a geriatric patient group in Taiwan: a 7-year survey from the outpatient clinic of a university medical center. Dermatol. 2001;203:308-13. doi: 10.1159/000051778.
  30. Bukvic Mokos Z., Jovic A., Ceovic R., et al. Therapeutic challenges in the mature patient. Clin Dermatol. 2018;36:128-39. Doi: 10.1016/j. clindermatol.2017.10.004.
  31. Weisshaar E., Szepietowski J.C., Darsow U., et al. European guideline on chronic pruritus. Acta Derm Venereol. 2012;92(5):563-81. doi: 10.2340/00015555-1400.
  32. Werfel T., Heratizadeh A., Aberer W., et al. S2k guideline on diagnosis and treatment of atopic dermatitis. Allergo J.Int. 2016;25:82-95. doi: 10.1007/s40629-016-0110-8.
  33. Wollenberg A., Barbarot S., Bieber T., et al. European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur AcadDermatol Venereol. 2018;32(5):657-82. doi: 10.1111/jdv.14891.
  34. Elman S., Hynan L.S., Gabriel V., Mayo M.J. The 5-D itch scale: a new measure of pruritus. Br J Dermatol. 2010;162(3):587-93. doi: 10.1111/j.1365-2133.2009.09586.x.
  35. Stephen-Haynes J., Carville K. Skin tears made easy. 2011. URL http://www.woundsinternational.com/made-easys/view/skin-tears-made-easy (last accessed 3 May 2018).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies