Molecular genetic aspects of the development of atopic dermatitis

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Abstract

Atopic dermatitis (AD) is one of the most common dermatoses in the world. It significantly reduces the quality of life of patients, and is a significant social and economic problem. Although the pathogenesis of AD is currently not fully understood, it is complex and appears to be the result of a combination of genetic and environmental factors that cause a defect in the epidermal barrier, an altered immune response, and an imbalance in the microbial balance of the skin. The study of the pathogenetic mechanisms of AD, the identification of its new components is an urgent problem due to the steady increase in the prevalence of the disease and can improve the efficiency of its diagnosis and treatment. The article presents a review of domestic and foreign literature sources devoted to the study of the most significant pathogenetic factors of AD.

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Anna S. Sysoeva

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Author for correspondence.
Email: sysojchik@yandex.ru
ORCID iD: 0009-0008-6981-464X
SPIN-code: 1026-7270

Teaching Assistant atof the Department of Medical Microbiology and Laboratory Medicine

Russian Federation, Penza

E. A. Orlova

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Email: sysojchik@yandex.ru
ORCID iD: 0000-0002-3902-2018
Russian Federation, Penza

О. А. Levashova

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Email: sysojchik@yandex.ru
ORCID iD: 0000-0002-8440-6598
Russian Federation, Penza

A. A. Turovskaya

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Email: sysojchik@yandex.ru
ORCID iD: 0000-0002-5138-808X
Russian Federation, Penza

L. R. Iskanderova

Penza Regional Children’s Clinical Hospital n.a. N.F. Filatov

Email: sysojchik@yandex.ru
ORCID iD: 0009-0005-7888-1156
Russian Federation, Penza

A. I. Kozina

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Email: sysojchik@yandex.ru
ORCID iD: 0009-0007-4931-8115
Russian Federation, Penza

E. M. Kostina

Penza Institute for Postgraduate Medical Education – Branch Campus of RMACPE

Email: sysojchik@yandex.ru
ORCID iD: 0000-0003-1797-8040
Russian Federation, Penza

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