Pyogenic granuloma of the nail bed, clinical cases and literature review
- Authors: Murakhovskaya E.K.1, Sysoeva T.A.1, Mertsalova I.B.1, Aleksandrova M.R.1
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 30, No 8 (2023)
- Pages: 35-41
- Section: Clinical experience
- URL: https://journals.eco-vector.com/2073-4034/article/view/623086
- DOI: https://doi.org/10.18565/pharmateca.2023.8.35-41
- ID: 623086
Cite item
Abstract
The article analyzes current information about pyogenic granuloma (PG), currently referred to as benign vascular tumors. The features of the clinical course of the disease are considered in detail, the factors that most often provoke the development of PG are described, a detailed description of the dermatoscopic picture is presented, with such signs as a reddish homogeneous area, white collar, white rail structures, ulceration and vascular structures. Special attention is paid to the differential diagnosis of PG with non-pigmented melanoma of the skin, Spitz nevus, lymphangiomas, angiokeratomas, bacillary angiomatosis, Kaposi’s sarcoma and basal cell skin cancer. The authors present their own clinical observations of PG in the nail bed, illustrating the possibility of self-regression, as well as the possibility of using a topical β-blocker for the treatment of PG in children.
Full Text
About the authors
Ekaterina K. Murakhovskaya
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: murakhovskayaek@mail.ru
ORCID iD: 0000-0002-3126-3618
SPIN-code: 2862-2889
Cand. Sci. (Med.), Teaching Assistant at the Department of Dermatovenereology and Cosmetology
Russian Federation, MoscowTatiana A. Sysoeva
Russian Medical Academy of Continuous Professional Education
Email: murakhovskayaek@mail.ru
ORCID iD: 0000-0002-3426-4106
SPIN-code: 1919-6461
Russian Federation, Moscow
Inna B. Mertsalova
Russian Medical Academy of Continuous Professional Education
Email: murakhovskayaek@mail.ru
ORCID iD: 0009-0000-3992-1032
SPIN-code: 5206-9083
Russian Federation, Moscow
M. R. Aleksandrova
Russian Medical Academy of Continuous Professional Education
Email: murakhovskayaek@mail.ru
Russian Federation, Moscow
References
- ISSVA Classification of Vascular Anomalies. Available at: https://www.issva.org/classification (Accessed 10.01.2023).
- Hullihen S.P. Case of aneurism by anastomosis of the superior maxillae. Am J Dent Sci. 1844;4:160–62.
- Hartzell M.B. Granuloma pyogenicum. J Cutan Dis Syph. 1904;22:520–25.
- Leung A.K.C., Barankin B., Hon K.L. Pyogenic Granuloma. Clinics Mother Child Health. 2014;11:e106. doi: 10.4172/2090-7214.1000e106.
- Gomes S.R., Shakir Q. J., Thaker P.V., Tavida J. K. Pyogenic granuloma of the gingiva: A misnomer? – A case report and review of literature. J Indian Soc Periodontol. 2013;17(4):514–19. doi: 10.4103/0972-124X.118327.
- Cherkaoui G.B., Souarji A., Oufkir A.A. Pyogenic granuloma after burns: a case report and review of the literature. Int J Burns Trauma 2022;12(3):127–30.
- Giffiths C.E.M., Barker J., Bleiker T.O. et al. Rooks Textbook of dermatology 9th ed. 2016. Vol. 4. 4696 p.
- Dinulos J.G.H. Habif’s clinical dermatology. A color Guide to Diagnosis and therapy. 7th ed. Elsevier, 2021. 1086 p.
- Wollina U. Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma Indian Dermatol Online J. 2018;9(5):293–98. doi: 10.4103/idoj.IDOJ_133_18.
- Usui S., Kogame T., Shibuya M., et al. Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills. J Dermatol. 2019;46(6):e202–3. doi: 10.1111/1346-8138.14762.
- Iraji F., Jelvan M., Ganjei Z. Multiple disseminated pyogenic granuloma post–oil burning—Review literature. Clin Case Rep. 2021;9:169–72. doi: 10.1002/ccr3.3491.
- Alessandrini A., Bruni F., Starace M., Piraccini B.M. Periungual Pyogenic Granuloma: The Importance of the Medical History. Skin Appendage Disord. 2016;1(4):175–78.
- Wollina U., Langner D., Franca K., et al. Pyogenic granuloma – A common benign vascular tumor with variable clinical presentation: new findings and treatment options. Maced J Med Sci. 2017;5:423–26. doi: 10.3889/oamjms.2017.111.
- Benedetto C., Crasto D., Ettefagh L., Nami N. Development of Periungual Pyogenic Granuloma with Associated Paronychia Following Isotretinoin Therapy: A Case Report and a Review of the Literature. J Clin Aesthet Dermatol. 2019;12(4):32–6.
- Sekkeli M. Z., Hosal M.B., Ocal E., et al. Conjunctival pyogenic granuloma during pregnancy. Arq Bras Oftalmol. 2021;84(5):490-493. doi: 10.5935/0004-2749.20210072. doi: 10.5935/0004-2749.20210072.
- Carolan A.M.C., Batie S.F., Caldwell K.M., et al. Urethral pyogenic granuloma in a pediatric patient. Urology Case Reports. 2022;45:102264. doi: 10.1016/j.eucr.2022.102264.
- Andrikopoulou M, Chatzistamou I, Gkilas H, et al. Assessment of angiogenic markers and female sex hormone receptors in pregnancy tumor of the gingiva. J Oral Maxillofac Surg. 2013;71(8):1376–81. doi: 10.1016/j.joms.2013.03.009.
- Yang Y., Ye X., Fu B., et al. Intravenous pyogenic granuloma in the internal jugular vein. A case report and literature review. Medicine. 2021;100(6):e24570. doi: 10.1097/MD.0000000000024570.
- Zelenik K., Kominek P., Stanikova L, Formanek M. Local Bevacizumab Treatment of Juvenile-Onset Respiratory Papillomatosis Might Induce Multiple Tracheal Pyogenic Granulomas. Laryngoscope. 2021;131(2):E518–20. doi: 10.1002/lary.28928.
- Acharya M.N., Kotidis K., Loubani M. Tracheal lobular capillary Haemangioma: a rare benign cause of recurrent Haemoptysis. Case Rep Surg. 2016;2016:6290424. doi: 10.1155/2016/6290424.
- Hijazi L.O., Asiri M., Mahdi M.J., Pharaon M. Pyogenic granuloma of the larynx. J Surg Case Rep. 2022;(7):rjac299. doi: 10.1093/jscr/rjac299.
- Paleti S., Fischer E. G., Rustagi T. Duodenal Pyogenic Granuloma. Clin Gastroenterol Hepatol. 2021;19(7):e73. doi: 10.1016/j.cgh.2020.04.064.
- Fujioka S., Hirakawa K., Fujita A., Esaki M. Gastric pyogenic granuloma arising from artificial ulcer scar created by endoscopic submucosal dissection. Dig Liver Dis. 2019;51(3):455. doi: 10.1016/j.dld.2018.09.019.
- Katta R., Bickle K., Hwang L. Pyogenic granuloma arising in port‐wine stain during pregnancy. Br J Dermatol. 2001;144(3):644–5. doi: 10.1046/j.1365-2133.2001.04114.x.
- Kim T.H., Choi E.H., Ahn S., Lee S.H. Vascular tumors arising in port-wine stains: two cases of pyogenic granuloma and a case of acquired tufted angioma. J Dermatol. 1999;26(12):813–16. doi: 10.1111/j.1346-8138.1999.tb02098.x.
- Тарасенко Г.Н., Тарасенко Ю.Г., Бекоева А.В., Процюк О. Пиогенная гранулема в практике врача дерматолога. Российский журнал кожных и венерических болезней. 2017;20(1):50–2. [Tarasenko G.N., Tarasenko Yu.G., Bekoeva A.V., Protsyuk O. Pyogenic granulema in dermatologist practice. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2017;20(1):50–2. (In Russ.)].
- Zaballos P., Carulla M., Ozdemir F., et al. Dermoscopy of pyogenic granuloma: a morphological study. Br J Dermatol. 2010;163(6):1229–37. doi: 10.1111/j.1365-2133.2010.10040.x.
- Silva T.S., Araujo L.R., Faro G.B.A., Paiva G.R. Nodular amelanotic melanoma. An Bras Dermatol. 2019;94(4):497–98. doi: 10.1590/abd1806-4841.20198453.
- Kaizer-Salk K.A., Herten R.J., Ragsdale B.D., Sengelmann R.D. Amelanotic melanoma: a unique case study and review of the literature BMJ Case Rep. 2018;2018:bcr2017222751. doi: 10.1136/bcr-2017-222751.
- Снарская Е.С., Олисова О.Ю., Васильева К.Д. Амеланоцитарная узловая меланома кожи у пациентки с отягощенным семейным анамнезом. Российский журнал кожных и венерических болезней. 2022;25(4):261–68. [Snarskaya E.S., Olisova O.Y., Vasileva K.D. Amelanotic nodular melanoma in a patient with a family history of skin cancers. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2022;25(4):261–68. (In Russ.)].
- Uyar B., Elmas O. F., Kilitci A. Dermatoscopic Features of Angiomatoid Spitz Nevus: a Case Report. Dermatol Pract Concept. 2022;12(4):e2022153. doi: 10.5826/dpc.1204a153.
- Sainz-Gaspar L., Sanchez-Bernal J, Noguera-Morel L., et al. Spitz Nevus and Other Spitzoid Tumors in Children -Part 1: Clinical, Histopathologic, and Immunohistochemical Features. Actas Dermosifiliogr (Engl Ed). 2020;111(1):7–19. doi: 10.1016/j.ad.2019.02.011.
- Zaballos P., Del Pozo L.J., Argenziano G., et al. Dermoscopy of lymphangioma circumscriptum: A morphological study of 45 cases. Australas J Dermatol. 2018;59(3):e189–93. doi: 10.1111/ajd.12668.
- Guillen-Climent S. et al. Angiokeratoma circumscriptum. Dermatol Online J. 2020;26(11):13030/qt8v6170qz.
- Megaly M., Boshra N. Pyogenic granuloma-like Kaposi’s sarcoma. Lancet. 2022;399(10335):e38. doi: 10.1016/S0140-6736(15)00467-5.
- Lins K.A., et al. Cutaneous manifestations of bartonellosis. An Bras Dermatol. 2019;94(5):594–602. doi: 10.1016/j.abd.2019.09.024.
- Fattore D., Di Duida A., Detoraki A. et al. Successful treatment of eruptive pyogenic granuloma with propranolol. Derm Ther. 2021;34(4):е14998. doi: 10.1111/dth.14998.
- Knоpfel N., Escudero-Gongora M., Bauza A., Martin-Santiago A. Timolol for the treatment of pyogenic granuloma (PG) in children. J Am Acad Dermatol. 2016;75(3):e105–6. doi: 10.1016/j.jaad.2016.03.036.
- Malik M., Murphy R. A pyogenic granuloma treated with topical timolol. Br J Dermatol. 2014;171(6):1537–38. doi: 10.1111/bjd.13116.
- Patra A.C., Sil A., Ahmet S.S., et al. Effectiveness and safety of 0.5% timolol solution in the treatment of pyogenic granuloma: A randomized, double-blind and placebo-controlled study. Indian J Dermatol Venereol Leprol. 2022;88(4):500–8. doi: 10.25259/IJDVL_565_20.
- Kelly K., Barry M.S., Marilyn G., et al. Topical treatment of pyogenic granulomas in a pediatric population: A single-institution retrospective review. JAAD Int. 2022;8:7–9. doi: 10.1016/j.jdin.2022.03.014.