Importance of the nitric oxide system in the development of psoriasis

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Abstract

Background. In recent years, psoriasis has been considered as a complex disease that combines signs of autoinflammatory and autoimmune processes. Issues of etiology and pathogenesis have not been finally elucidated and continue to be discussed. The inflammatory component is one of the essential links in the pathogenesis of psoriasis, which occurs with recurrent exacerbations, accompanied by an inflammatory reaction of varying severity.

Objective. Evaluation of the features of blood serum nitric oxide (NO) production in patients with various clinical forms of psoriasis.

Methods. The state of the blood serum NO system in 121 patients with psoriasis was assessed. In the blood serum of psoriatic patients, there was a high concentration of the main stable metabolites of NO, which may be one of the reasons for the development of this disease. At the same time, there was a clear dependence of blood serum NO expression on the clinical form of psoriasis.

Results. iNOS, ONO2-, and ET-1 expression is among the causes of high blood serum NO levels in patients with psoriasis. It is possible that these interrelated processes reflect the general reaction of the organism of patients to a damaging factor, depending on the clinical forms of psoriasis.

Conclusion. Thus, the NO level, which is an important link in the system of nonspecific reactivity of the body, occupying an important place in the pathogenesis of psoriasis, can be considered as one of the modern highly sensitive criteria for inflammation. Determining the NO level makes it possible to objectively assess the intensity of the inflammatory reaction, the activity of the pathological process, the effectiveness of therapy, and also the prognosis of dermatosis.

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About the authors

Saidnairkhon F. Alyavi

Tashkent State Dental Institute

Author for correspondence.
Email: anair72@mail.ru
ORCID iD: 0009-0003-4128-0387

Cand. Sci. (Med.), Associate Professor at the Department of Therapeutic Subjects

Uzbekistan, Tashkent

A. B. Rakhmatov

Republican Specialized Scientific and Practical Medical Center for Dermatology, Venereology and Cosmetology

Email: anair72@mail.ru
ORCID iD: 0009-0005-7416-1223
Uzbekistan, Tashkent

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