Delay of initiation of adjuvant chemotherapy in patients with early breast cancer: causes and consequences

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Abstract

Adjuvant chemotherapy (ACT) for breast cancer (BC) has been successfully used as part of complex treatment for several decades. The concept of BC as a systemic disease has made it possible to develop optimal treatment algorithms, including both local methods of disease control, such as surgery and radiation therapy, and systemic drug treatment. The effectiveness of adjuvant systemic therapy in increasing overall and relapse-free survival is not in doubt, however, the optimal timing of initiation of chemotherapy after radical surgical treatment has not been reliably determined to date. Many factors, such as age, comorbidity, type of surgery, and patient compliance with treatment, can delay chemotherapy. We analyzed the largest studies in this area to gain insight into what may cause delays in adjuvant treatment and the long-term consequences of such delays for the patient.

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G. A. Dashyan

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Author for correspondence.
Email: dgarik@mail.ru
ORCID iD: 0000-0001-6183-9764
SPIN-code: 6989-7148
Scopus Author ID: 17344871400

Dr. Sci. (Med.), Head of Oncology Department № 1 (Surgical Methods for the Treatment of Tumors of the Breast, Skin and Soft Tissues)

Russian Federation, St. Petersburg

V. V. Konstantinova

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0001-9650-7305
Russian Federation, St. Petersburg

E. S. Dzhelialov

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0002-2571-243X
SPIN-code: 7261-2325
Russian Federation, St. Petersburg

R. M. Akhmedov

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0003-3348-4251
Russian Federation, St. Petersburg

Yu. V. Semiletova

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0001-5706-250X
Russian Federation, St. Petersburg

A. S. Zhurov

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0009-0004-7511-2952
Russian Federation, St. Petersburg

A. E. Tyusenko

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0003-0689-6058
SPIN-code: 9223-5741
Russian Federation, St. Petersburg

A. A. Olchonova

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
Russian Federation, St. Petersburg

I. A. Pavlikova

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0002-1753-6296
Russian Federation, St. Petersburg

A. M. Belousov

Clinic of High Medical Technologies n.a. N.I. Pirogov, St. Petersburg State University

Email: dgarik@mail.ru
ORCID iD: 0000-0002-2274-8170
Russian Federation, St. Petersburg

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