Modern ideas about non-tumor melanin hyperpigmentation

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Abstract

Melanin hyperpigmentation (HP) is a fairly common reason for visiting dermatologists and cosmetologists. In clinical practice, melasma and secondary post-inflammatory HPs are the most common. Tyrosinase is considered to be the key enzyme in the melonogenesis disorder. At the same time, inhibition of the tyrosinase enzyme activity is the safest and most effective way to reduce HP today. However, the clinical effectiveness of current tyrosinase inhibitors is limited due to the fact that they have generally been selected based on their ability to inhibit fungal tyrosinase. In recent studies, thiamidol has been characterized as a particularly potent inhibitor of human tyrosinase. In vitro, thiamidol was superior to commonly used HP inhibitors such as arbutin, kojic acid, and hydroquinone. This superiority of thiamidol compared to hydroquinone was confirmed in studies in vivo.

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About the authors

L. S. Kruglova

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Author for correspondence.
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265

Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology

Russian Federation, Moscow

A. V. Bezborodova

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: pharmateca@yandex.ru
ORCID iD: 0009-0007-6213-9496
Russian Federation, Moscow

N. V. Gryazeva

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: pharmateca@yandex.ru
ORCID iD: 0000-0003-3437-5233
Russian Federation, Moscow

A. T. Semizidis

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: pharmateca@yandex.ru
ORCID iD: 0009-0007-5413-0125
Russian Federation, Moscow

A. L. Bakulev

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: pharmateca@yandex.ru
ORCID iD: 0000-0002-1450-4942
Russian Federation, Moscow

R. A. Ravodin

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

Email: pharmateca@yandex.ru
ORCID iD: 0000-0002-0737-0317
Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Рис. 1. Схематическое изображение меланогенеза, индуцированное УФ-излучением

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3. Рис. 2. Черный акантоз

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4. Рис. 3. Артифициальная меланодермия, связанная с экстравазацией препарата железа при внутривенном введении

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5. Рис. 4. Мелазма

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6. Рис. 5. Поздняя кожная порфирия

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7. Рис. 6. Гиперпигментация на месте разрешившихся элементов буллезного дерматоза

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8. Рис. 7. Токсидермия

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9. Рис. 8. Красный плоский лишай (пигментная форма)

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10. Рис. 9. Атрофодермия Пазини-Пьерини

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11. Рис. 10. Почесуха

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12. Рис. 11. Фиксированная эритема

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13. Рис. 12. Поствоспалительная ГП (симптомокомплекс постакне)

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14. Рис. 13. Поствоспалительная ГП после фотофитодерматоза

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15. Рис. 14. ГП после терапии с использованием пиявок

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16. Рис. 15. ГП после "постановки банок"

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17. Рис. 16. ГП после лазерной терапии

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