Features of liver damage in patients with thyrotoxicosis: clinical observation of hepatopathy against the background of taking thyreostatics

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Abstract

Metabolic processes in the liver are closely related to the work of the thyroid gland. In this regard; it is necessary to exclude the pathology of the thyroid gland with an increase in the transaminase level for an unknown reason. It is known that diffuse toxic goiter is the leading cause of thyrotoxicosis. In patients with newly diagnosed hyperthyroidism; biochemical abnormalities in the blood test; indicating liver dysfunction; are recorded quite often; while clinical manifestations; as a rule; may not be expressed. The article discusses the issues of diagnosing hepatopathy in patients with thyrotoxicosis; the need to differentiate true thyrotoxic damage from concomitant liver diseases of a viral and autoimmune nature; drug-induced liver damage. The authors present a clinical case of acute toxic hepatitis caused by thiamazole in a patient with diffuse toxic goiter.

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About the authors

Svetlana V. Bulgakova

Samara State Medical University

Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0003-0027-1786
Russian Federation, Samara

Lyudmila A. Sharonova

Samara State Medical University

Author for correspondence.
Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0001-8827-4919

Cand. Sci. (Med.), Associate Professor; Department of Endocrinology and Geriatrics

Russian Federation, Samara

Yuliya A. Dolgikh

Samara State Medical University

Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0001-6678-6411
Russian Federation, Samara

Olga V. Kosareva

Samara State Medical University

Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0002-5754-1057
Russian Federation, Samara

Ekaterina V. Treneva

Samara State Medical University

Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0003-0097-7252
Russian Federation, Samara

Dmitry P. Kurmaev

Samara State Medical University

Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0003-4114-5233
Russian Federation, Samara

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