No 8 (2009)

Beta-blockers (BB) are associated with decreasing of mortality and other cardiovascular endpoints in patients with arterial hypertension (AH), acute and chronic forms of ischemic heart disease (IHD). BB are especially effective in decreasing of fatal ventricular arrhythmias in patients with high risk of sudden cardiac death. Selective beta1-BB without intrinsic sympathomimetic activity bisoprolol is characterized by high bioavailability, long elimination half-life, well-balanced clearance. Clinical studies demonstrated positive effect of bicoprolol on cardiovascular morbidity and mortality in patients with AH and IHD.

The article includes discussion of the problem of intrahepatic cholestatasis (IC), which can be the syndrome of acute and chronic liver diseases and separate disease with morphologic and biochemistry changes caused by disorders of bile outflow. The article describes the approaches to treatment using drugs affecting different stages of pathogenesis: geptral - bioactive compound and analog of natural in cellular ademetionine and ursodeoxycholic acid drugs (UAD). Geptral is a hepatoprotector with antidepressive activity and choleretic and cholekinetic action, detoxication, regeneration, antioxidant, antifibrotic and neuroprotective effects. UAD cause the decreasing of the concentration of hydrophobic bile acids in enterohepatic circulation, preventing its toxic effect on hepatocyte membranes and epithelium of biliary duct, and also have immunomodulating and anti-inflammatory effect.

It describes characteristics of lipid metabolism in normal pregnancy and pregnancy, complicated by hypertension, preeclampsy and gestational diabetes. It includes the discussion of the impact of lipid profile disturbances on the cardiovascular risk and prognosis of the mother and child.

Chronic gastritis (CG) is one of the most prevalent diseases of gastrointestinal tract, which is asymptomatic in the large share of the patients. The main etiologic factor of CG is microorganism Helicobacter pylori, which persistence in gastric mucosa can cause the consequential development of chronic active inflammation, atrophy, metaplasia, metaplasi and in some cases - gastric cancer. Other forms of gastritis (autoimmune, chemical, lymphocytic and other) are rare. Treatment of CG includes the elimination of etiological factor, and if it is unknown, - on the main stages of pathogenesis and decreasing of disease symptoms. In in treatment of CG associated with Helicobacter pylori, it is preferably to use four component scheme. Therapy of other form comes down to symptoms decreasing.

The article dedicated to the modern insight on etiology, pathogenesis, clinic and diagnostic of syndrome of the irritable bowel (SIB). It justifies the necessity of providing complex therapy of different forms of SIB with help of psychologists and psychiatrics. It describes the main methods of treatment of SIB, including probiotics such as metabolic probiotic Chilak-forte.

The comparative study of the efficiency of the start antibacterial therapy of acute intestinal infections in 130 children aged from 1 month till 3 years with different forms of diarrhea syndrome by Enterofuril, furazolidone, amikasin. It was established that using Enterofuril as a start treatment of moderate and severe forms (in the combination with antibiotics) of invasive and mixed diarrhea allowed to achieve more quick effect compared with other drugs, especially concerning local disease symptoms, with minimal disturbances of microbiocenosis during the reconvalescence period. It is reasonable to include Enterofuril in start etiotropic therapy of osmolar diarrhea during first 3 days before revealing the etiologic factor of the acute intestinal infection.