No 15-2 (2014)

The article presents the modern views on the principles of use, mechanisms of action, contraindications and indications for the use of sublingual allergen-specific immunotherapy (SASI). The advantages of the method are discussed in detail. The comparative characteristic of SASI and subcutaneous immunotherapy is demonstrated. Adherence to the principles of rational pharmacotherapy makes tableted SASI a first-line choice for persons with respiratory allergies.

Violation of the barrier function, provoking the development of xerosis of the skin remains constant symptom of most chronic dermatoses with the localization of the pathological process on the feet and is quite common in various somatic diseases. There are many predictors of foot xerosis, and the consequences are very serious; so, the treatment should be started after the verification of the diagnosis and in two ways: treatment of the underlying disease and the elimination of the symptoms themselves. The article presents the clinical observations the use of drugs Balzamed® by patients with chronic dermatoses with the localization of process on the feet. All patients received comprehensive treatment in accordance with medical standards at each of the listed diseases. As a basic therapy, patients used the cream Balzamed® intensive 2 times a day for 1.0-1.5 months, then - cream Balzamed® up to 4 times a day for 6 months. In patients with palmoplantar psoriasis, tylotic eczema, and keratoderma, basic therapy with drugs Balzamed® has a universal effect, causing the recovery of barrier function of the skin, which is the mainstay of high therapeutic and prophylactic efficacy.

Physiological changes during pregnancy can alter the course of bronchial asthma - mainly to the more severe disease. Uncontrolled course of the disease leads to a higher risk of complications during pregnancy (pre-eclampsia, bleeding, malnutrition and LBW, neonatal hypoxia, intrauterine infection, etc.). Pregnancy is not contraindication to adequate pharmacotherapy of bronchial asthma; the choice of drugs should be based on their potential safety for the fetus.

Immunodeficiency is a reduction of functional activity of the main components of the immune system, leading to a failure of the body's defense against infectious agents, and manifested in increased incidence of infectious diseases. Immunodeficiency disorders are considered as the main point of application of immunomodulators. The article presents the current classification and characterization of immunomodulatory drugs used in pediatric practice for the prevention and treatment. The indications for use of different groups of immunomodulators are discussed; data on their effectiveness in the treatment of recurrent respiratory infection children are presented. The advisability of immunomodulatory therapy in long-standing and often recurrent infectious processes with immune disorders identified in children is emphasized.