MYELODYSPLASTIC SYNDROME AND IRON OVERLOAD: RESULTS OF SCREENING EXAMINATION OF 289 PATIENTS


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Abstract

The data for screening examination of iron metabolism in 289 patients with myelodysplastic syndrome (MDS) are presented. Screening was aimed to identify the category of patients who may benefit from chelator therapy. The data analysis suggests that iron overload is one of the characteristic symptoms in patients with low risk MDS, especially in the case of donor red blood cells transfusion. Thereby, chelator therapy should be an integral part of treatment in patients with MDS. Administration of iron chelators for patients with MDS should be preceded by analyses of the clinical and laboratory indices, including the number of packed red blood cell unit transfusions, serum ferritin level, and transferrin saturation level.

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