SAXAGLIPTIN (ONGLYZA ®) IN CONCEPTION OF EFFECTIVE MANAGEMENT OF TYPE 2 DIABETES MELLITUS


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Abstract

Effective management of type 2 diabetes mellitus (DM2) is one of the most topical problems of modern diabetology. This is determined by progressive nature of the disease and treatment complications (hypoglycemia and weight gain), which develop on the background of a number of oral glucose-lowering drugs and have significant effect not only on treatment compliance of DM2 patients, but also on risk of cardiovascular diseases. In this regard, strict requirements for efficiency and safety of modern pharmacotherapy of type 2 diabetes mellitus are required. Saxagliptin - dipeptidyl peptidase-4 inhibitor - meets these criteria. Saxagliptin belongs to a new group of antidiabetic drugs; its glycose-dependent action is based on the effect of incretins. Clinical studies have confirmed the efficacy and safety of saxagliptin in DM2 patients both as monotherapy and in combination with other antidiabetic drugs.

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