Evaluation of the vitamin D deficiency study in patients with benign paroxysmal positional vertigo: a retrospective clinical study


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Abstract

Background. Benign paroxysmal positional vertigo (BPPV) remains the most common cause of systemic vertigo with a relapsing course of the disease. The causes of relapse are not clear. There is a theory that the cause of relapses of BPPV is a vitamin D (25(OH)D) deficiency, which also results in a more severe course of the disease. Objective. Determination of the relationship between the serum 25(OH)D level, relapses, and the severity of the BPPV course. Methods. The main group consisted of 40 patients with BPPV, the control group consisted of 30 patients with other established diseases of the vestibular system (central and peripheral genesis), comparable in demographic indicators. In both groups, serum 25(OH)D levels were evaluated. To determine the relationship between the 25(OH)D level and the course of the disease, medical history was analyzed, and Dizziness Handicap Inventory (DHI), a visual analogue scale of vertigo (VAS-v), and Hospital Anxiety and Depression Scale (HADS) were used. Results. Compared to the control group, patients with BPPV had lower 25(OH)D level (p<0.05). In patients with recurring forms of BPPV, the 25(OH)D level was lower than in patients with a single relapse of the disease (p<0.01). Patients with the 25(OH)D level <12 ng/ml had a higher DHI (p<0.05) and VAS (p<0.05) score compared with patients with the 25(OH)D level of >12 ng/ml. Conclusion. 25(OH)D deficiency is a risk factor for the development of BPPV, contributing to more frequent relapses and a severe course of the disease.

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About the authors

Aleksandr Yu. Kazantsev

Kazan State Medical University, Department of Neurology, Neurosurgery and Medical Genetics

Email: engine90@bk.rn
Teaching Assistant, Department of Neurology, Neurosurgery and Medical Genetics Kazan, Russia

E. Z Yakupov

Kazan State Medical University, Department of Neurology, Neurosurgery and Medical Genetics; Research Medical Complex “Your Health"

Kazan, Russia

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