Therapeutic use of amaranth oil: current trends and prospects of use
- Authors: Mubarakshina O.A.1, Batishcheva G.A.1, Zhdanova O.A.1, Volynkina A.P.1, Grechushkina I.V.2
-
Affiliations:
- Voronezh State Medical University named after N.N. Burdenko
- Voronezh City Polyclinic No. 10
- Issue: Vol 32, No 4 (2025)
- Pages: 42-47
- Section: Gastroenterology/nutriciology
- URL: https://journals.eco-vector.com/2073-4034/article/view/687697
- DOI: https://doi.org/10.18565/pharmateca.2025.4.42-47
- ID: 687697
Cite item
Abstract
In recent years, there has been a growing interest in the use of plant products as effective means of preventing and treating various diseases. In this regard, it is of interest to study the pharmacological properties and therapeutic effects of amaranth oil. An important active ingredient of this product is squalene, which has antioxidant, regenerating, immunomodulatory, hypocholesterolemic effects. Other components of amaranth oil act in synergy with squalene: polyunsaturated fatty acids, phospholipids, vitamin E, etc. The presence of these biologically active compounds justifies the use of amaranth oil in various diseases, including chronic venous insufficiency, cardiovascular diseases, type 2 diabetes mellitus and a number of other pathologies. Modern technology for extracting oil from amaranth germs provides a high concentration of beneficial nutrients and preservation of all pharmacological properties. Available experimental and clinical data allow to recommend amaranth oil as an effective supplement to traditional methods of treatment and prevention of various diseases.
Full Text

About the authors
Olga A. Mubarakshina
Voronezh State Medical University named after N.N. Burdenko
Author for correspondence.
Email: mubarakshina@mail.ru
ORCID iD: 0000-0001-6799-6322
Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology
Russian Federation, VoronezhGalina A. Batishcheva
Voronezh State Medical University named after N.N. Burdenko
Email: bat13@mail.ru
ORCID iD: 0000-0003-4771-7466
Dr. Sci. (Med.), Professor, Head of the Department of Clinical Pharmacology
Russian Federation, VoronezhOlga A. Zhdanova
Voronezh State Medical University named after N.N. Burdenko
Email: olga.vr9@yandex.ru
ORCID iD: 0000-0002-3917-0395
Dr. Sci. (Med.), Associate Professor, Professor, Department of Clinical Pharmacology
Russian Federation, VoronezhAnna P. Volynkina
Voronezh State Medical University named after N.N. Burdenko
Email: ovp.idpo@vrngmu.ru
ORCID iD: 0000-0001-8942-6224
Cand. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Endocrinology
Russian Federation, VoronezhIrina V. Grechushkina
Voronezh City Polyclinic No. 10
Email: irina1984grechushkina@gmail.com
ORCID iD: 0009-0004-6815-8151
Cand. Sci. (Med.), General Practitioner, Day Hospital
Russian Federation, VoronezhReferences
- Попов В.И., Бавыкина И.А., Звягин А.А. и др. Значение продуктов из амаранта в диетическом рационе питания детей с непереносимостью глютена. Вопросы питания. 2024;93(4):14–21. [Popov V.I., Bavykina I.A., Zvyagin A.A., et al. The importance of amaranth products in the diet of children with gluten intolerance. Voprosy pitaniia=Problems of Nutrition. 2024;93(4):14–21. (In Russ)]. https://doi.org/10.33029/0042-8833-2024-93-4-14-21
- Джавахян М.А., Магомедова Л.И., Алешникова К.Ю. и др. Амарант – перспективный источник получения сквалена. Вопросы обеспечения качества лекарственных средств. 2023;(2):47–58. [Dzhavakhyan M.A., Magomedova L.I., Aleshnikova K.Yu., et al. Amaranth is a promising source of squalene. Issues of quality assurance of medicines. 2023;(2):47–58. (In Russ)]. https://www.doi.org/10.34907/JPQAI.2023.26.77.007
- Nikolaevsky V.A., Martirosyan D.M., Muzalevskaya E.N., et al. Hepatotropic, antioxidant and antitoxic action of amaranth oil. Funct Foods Health Dis. 2014;4(5):159–171.
- Музалевская Е.Н. Экспериментальное обоснование применения масла семян амаранта для коррекции осложнений, вызываемых изониазидом. Автореферат дисс. канд. мед. наук. Волгоград, 2016. [Muzalevskaya E.N. Experimental substantiation of the use of amaranth seed oil for the correction of complications caused by isoniazid. Abstract of the Diss. Cand. of Med. Sciences. Volgograd, 2016. (In Russ)]. URL: https://www.volgmed.ru/uploads/dsovet/autoref/2-698-1453207367_muzalevskaya_ekaterina_nikolaevna.pdf
- Музалевская Е.Н., Мирошниченко Л.А., Николаевский В.А. и др. Сквален: физиологические и фармакологические свойства. Экспериментальная и клиническая фармакология. 2015;78(6):30–36. [Muzalevskaya E.N., Miroshnichenko L.A., Nikolaevsky V.A. et al. Squalene: physiological and pharmacological properties. Experimental and Clinical Pharmacology. 2015;78(6):30–36. (In Russ)]. https://doi.org/10.30906/0869-2092-2015-78-6-30-36
- Михеева Л.А., Брынских Г.Т., Якубова А.Р. Экстракция амарантового масла и изучение его физико-химических свойств. Ульяновский медико-биологический журнал. 2014;(3):139–144. [Mikheeva L.A., Brynskikh G.T., Yakubova A.R. Extraction of amaranth oil and study of its physicochemical properties. Ulyanovsk Medical and Biological Journal. 2014;(3):139–144. (In Russ)].
- Jackson K.H., Harris W.S., Belury M.A., et al. Beneficial effects of linoleic acid on cardiometabolic health: an update. Lipids Health Dis. 2024;23:296. https://doi.org/10.1186/s12944-024-02246-2
- Сафонова Е.Ф. Выделение и изучение фосфолипидов масла семян амаранта. Автореферат дисс. канд. фарм. наук. Москва, 2004. [Safonova E.F. Isolation and study of amaranth seed oil phospholipids. Abstract of Diss. Cand. of Pharm. Sciences. Moscow, 2004. (In Russ)]. URL: https://viewer.rsl.ru/ru/rsl01002729756?page=1&rotate=0&theme=white
- Селеменев В.Ф., Макеев В.Ф., Корейская И.М., и др. Изучение фосфолипидного состава амарантового масла. Материалы IV Международного симпозиума «Новые и нетрадиционные растения и перспективы их использования». Москва-Пущино, 2001. С. 99–101. [Selemenev V.F., Makeev V.F., Koreyskaya I.M., et al. Study of the phospholipid composition of amaranth oil. Proceedings of the IV International Symposium «New and Unconventional Plants and Prospects for Their Use». Moscow-Pushchino, 2001. P. 99–101. (In Russ)].
- Rizvi S., Raza S.T., Ahmed F., et al. The role of vitamin E in human health and some diseases. Sultan Qaboos Univ Med J. 2014;14(2):e157–e165. https://doi.org/10.12816/0003296
- Sandoval-Sicairos E.S., Milan-Noris A.K., Luna-Vital D.A., et al. Anti-inflammatory and antioxidant effects of peptides released from germinated amaranth during in vitro simulated gastrointestinal digestion. Food Chemistry. 2021;343:128394. https://doi.org/10.1016/j.foodchem.2020.128394
- Venskutonis P.R., Kraujalis P. Nutritional components of amaranth seeds and vegetables: a review on composition, properties, and uses. Compr Rev Food Sci Food Saf. 2013;12(4):381–412. https://doi.org/10.1111/1541-4337.12021
- Czerwinski J., Bartnikowska E., Leontowicz H., et al. Oat (Avena sativa L.) and amaranth (Amaranthus hypochondriacus) meals positively affect plasma lipid profile in rats fed cholesterol-containing diets. J Nutr Biochem. 2004;15(10):622–629. https://doi.org/10.1016/j.jnutbio.2004.06.002
- Park S.J., Sharma A., Lee H.J. A review of recent studies on the antioxidant activities of a third-millennium food: Amaranthus spp. Antioxidants (Basel). 2020;9(12):1236. https://doi.org/10.3390/antiox9121236
- Музалевская Е.Н., Николаевский В.А., Чернов Ю.Н., Мирошниченко Л.А. Средство для улучшения микроциркуляторных процессов в организме и способ его использования. Патент № 2646463 Российская Федерация, заявл. 18.08.2015, опубл. 27.02.2017. [Muzalevskaya E.N., Nikolaevsky V.A., Chernov Yu.N., Miroshnichenko L.A. Agent for improving microcirculatory processes in the body and a method for its use. Patent No. 2646463 Russian Federation, declared 18.08.2015, published 27.02.2017. (In Russ)]. URL: https://www1.fips.ru/iiss/document.xhtml?faces-redirect=true&id=d170e80a69d12de4ec90e2c53b003e66
- De Vita D., Messore A., Toniolo C., et al. Towards a new application of amaranth seed oil as an agent against Candida albicans. Natural Product Research. 2021;35(22):4621–4626. https://doi.org/10.1080/14786419.2019.1696335
- Wolosik K., Chalecka M., Palka J., et al. Amaranthus cruentus L. seed oil counteracts UVA-radiation-induced inhibition of collagen biosynthesis and wound healing in human skin fibroblasts. Int Journal Mol Sci. 2024;25:925. 0.3390/ijms25020925
- Martirosyan D.M., Miroshnichenko L.A., Kulakova S.N., et al. Amaranth oil application for coronary heart disease and hypertension. Lipids Health Dis. 2007;6:1. https://doi.org/10.1186/1476-511X-6-1
- Погожева А.В., Кулакова С.Н., Медведев Ф.А., и др. Влияние масла амаранта на показатели липидного обмена у больных ишемической болезнью сердца и гиперлипопротеидемией. Voprosy pitaniia=Problems of Nutrition 2006;(3):17–21. [Pogozheva A.V., Kulakova S.N., Medvedev F.A., et al. Effect of amaranth oil on lipid metabolism indices in patients with ischemic heart disease and hyperlipoproteinemia. Nutrition issues. 2006;(3):17–21. (In Russ)].
- Коренская И.М., Ивановская Н.П. Изучение ранозаживляющего действия масла из семян амаранта в эксперименте. Материалы межрегиональной научно-практической конференции «Проблемы здоровьесбережения школьников и студентов. Новые научные тенденции в медицине и фармации». Воронеж, 2008. С. 223–225. [Korenskaya I.M., Ivanovskaya N.P. Study of the wound-healing effect of amaranth seed oil in an experiment. Proceedings of the interregional scientific and practical conference «Problems of health preservation of schoolchildren and students. New scientific trends in medicine and pharmacy». Voronezh, 2008, P. 223–225. (In Russ)].
- Медведев А.Е. Лечебный препарат «АМАФОР-250». Патент № 2214264 Российская Федерация, заявл. 17.07.2002, опубл. 20.10.2003. [Medvedev A.E. Therapeutic drug «AMAFOR-250». Patent No. 2214264 Russian Federation, declared 17.07.2002, published 20.10.2003. (In Russ)]. URL: https://www1.fips.ru/iiss/document.xhtml?faces-redirect=true&id=a2b0738a0275f772a8c57f3b926ca16f
- Kelly G.S. Squalene and its potential clinical uses. Alternative Medicine Review. 1999;4(1):29–36.
- Волынкина А.П. Клиническая эффективность лечения сахарного диабета 2 типа в сочетании с артериальной гипертензией включением в терапию масел на основе амаранта и подсолнечника. Автореферат дисс. кандидата медицинских наук. Воронеж, 2008. [Volynkina A.P. Clinical efficiency of treatment of diabetes mellitus type 2 in combination with arterial hypertension by inclusion of oils based on amaranth and sunflower in therapy. Abstract of Diss. Cand. of Med. Sciences. Voronezh, 2008. (In Russ)].
- Николаевский В.А., Золоедов В.И., Лобеева Н.В., и др. Лечебное средство профилактики и лечения хронических заболеваний печени. Патент № 2526172 Российская Федерация, заявл. 10.02.2012, опубл. 20.08.2014. [Nikolaevsky V.A., Zoloedov V.I., Lobeeva N.V., et al. A therapeutic agent for the prevention and treatment of chronic liver diseases. Patent No. 2526172 Russian Federation, declared 10.02.2012, published 20.08.2014. (In Russ)]. URL: https://www1.fips.ru/iiss/document.xhtml?faces-redirect=true&id=4b2b0b4085591798fb15cd2e842bcb35
- Campos Herrera A., Valenzuela Zamudio F., Segura Campos M.R. Therapeutic effects of amaranth: analysis of the antidiabetic potential of the plant. J Med Food. 2024;27(4):279–286. https://doi.org/10.1089/jmf.2022.0159
- Reddy L.H., Couvreur P. Squalene: a natural triterpene for use in disease management and therapy. Adv Drug Deliv Rev. 2009;61(15):1412–1426. https://doi.org/10.1016/j.addr.2009.09.005
- Макеев A.M., Мирошниченко Л.А., Суровцев И.С., и др. Регенерационные и противоопухолевые свойства амарантового масла. Материалы III международного симпозиума «Новые и нетрадиционные растения и перспективы их использования». Москва-Пущино, 1999. С. 100–103. [Makeev A.M., Miroshnichenko L.A., Surovtsev I.S., et al. Regenerative and antitumor properties of amaranth oil. Proceedings of the III International Symposium «New and Unconventional Plants and Prospects for Their Use». Moscow-Pushchino, 1999. P. 100–103. (In Russ)].
- Ferrari S., Galla R., Mulè S., et al. Analysis of the combined effects of a novel combination of hypersmin, pumpkin seed and Amaranthus extracts in an in vitro model of chronic venous insufficiency. Nutrients. 2025;17(11):1807. https://doi.org/10.3390/nu17111807
Supplementary files
