Travelers’ diarrhea in children: risk factors, clinical features, and therapeutic recommendations

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Resumo

Background: Travelers’ diarrhea (TD) is one of the most common forms of infectious diarrhea. Despite the fact that the problem of TD in children has attracted the attention of infectious disease specialists and pediatricians for several decades, ideas about the epidemiology, clinical and laboratory features of the course and tactics of prehospital and inpatient treatment require further clarification.

Objective: Identification of the nosological structure, features of the clinical course, the effectiveness of the therapy used in children with travelers’ diarrhea (TD).

Materials and methods: The retrospective, non-randomized, two-center study was conducted. The study randomly included 394 patients treated in the period 2021-2024 with travelers’ diarrhea. The data of the epidemiological history, clinical follow-up of patients, laboratory examination were evaluated, and a clinical and laboratory comparison of the effectiveness of nifuroxazide for TD was carried out.

Results: A significant role of both viral and bacterial pathogens in the development of diarrhea in children was shown, as well as frequent detection of excessive growth of opportunistic microorganisms in this pathology, as well as the positive effects of taking nifuroxazide in early empirical therapy and in a 24-hour hospital settings.

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Sobre autores

Milana Alagova

Federal Scientific and Clinical Center for Infectious Diseases, Federal Medical and Biological Agency

Email: milana.alagova@yandex.ru
ORCID ID: 0009-0002-8967-2059

full-time postgraduate student

Rússia, St. Petersburg

Vyacheslav Ratnikov

Federal Scientific and Clinical Center for Infectious Diseases, Federal Medical and Biological Agency; St. Petersburg State University

Email: dr.ratnikov@mail.ru
ORCID ID: 0000-0002-9645-8408

Dr. Sci. (Med.), Professor, Acting Director General, Federal Scientific and Clinical Center for Infectious Diseases, Professor, Department of Radiation Diagnostics

Rússia, St. Petersburg; St. Petersburg

Irina Razdyakonova

Federal Scientific and Clinical Center for Infectious Diseases, Federal Medical and Biological Agency

Email: ermolenko.kd@yandex.ru

Cand. Sci. (Med.), Head of the Department of Intestinal Infections

Rússia, St. Petersburg

Konstantin Ermolenko

Federal Scientific and Clinical Center for Infectious Diseases, Federal Medical and Biological Agency; St. Petersburg State University

Autor responsável pela correspondência
Email: ermolenko.kd@yandex.ru
ORCID ID: 0000-0003-3643-7354

Dr. Sci. (Med.), Head of the Research Institute of Intestinal Infections, Associate Professor, Department of Infectious Diseases

Rússia, St. Petersburg; St. Petersburg

Ksenia Silav

Federal Scientific and Clinical Center for Infectious Diseases, Federal Medical and Biological Agency; S.P. Botkin Clinical Infectious Diseases Hospital

Email: ermolenko.kd@yandex.ru
ORCID ID: 0009-0008-0264-9504

postgraduate student, Research Department of Intestinal Infections, Physician

Rússia, St. Petersburg; St. Petersburg

Anna Ratnikova

L.G. Sokolov North-West District Scientific and Clinical Center, Federal Medical and Biological Agency

Email: ermolenko.kd@yandex.ru
ORCID ID: 0000-0003-3279-6448

Cand. Sci. (Med.) Senior Researcher

Rússia, St. Petersburg

Bibliografia

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2. Figure 1. Regions visited by children with traveler's diarrhea

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3. Figure 2. Results of the study of children's feces using the PCR method (n=394)

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