PROHEPAR EFFECTIVENESS IN EXPERIMENTAL ALCOHOL-INDUSED AND PARACETAMOL-INDUCED LIVER DAMAGE: BIOCHEMISTRY AND HISTOLOGY

Prohepar is synergistic hepatoprotective combination based on liver hydrolysate received from bullocks and enriched by cyanocobalamin, choline, myo-inositol and cysteine. The available data for the experimental and clinical pharmacology of Prohepar and its components indicate its undoubted hepatoprotective effect. The authors for the first time have investigated experimental changes in biochemical markers of liver function and histology of liver tissue, as well as other organs in alcohol- and paracetamol-induced liver damage against the background of therapy with Prohepar. Improvement in functional and structural state of the liver against the background of use of Prohepar was shown. Hepatoprotective effect was most noticeable on the model of alcohol-induced liver injury. Histological examination of tissue samples showed a marked morphological differences, which were expressed in radically different degrees of damage of parenchymal cells and circulatory disturbances. Revealed differences in the structure of liver tissue, as well as changes in biochemical markers levels, indicate pronounced protective effect of Prohepar in alcohol- or acetaminophen-induced liver damages.

alcohol intoxication of liver, paracetamol-indused liver injury, Wistar rats, Prohepar