Gastroezofageal'naya reflyuksnaya bolezn' kak kislotozavisimoe zabolevanie, mesto antisekretorykh preparatov v ee lechenii

In recent decade, gastroesophageal reflux disease (GERD) is attracting more attention due to the marked tendency to increasing the frequency of its occurrence. Significance of GERD is determined not only by its prevalence, but also by complicated course of disease. Over the last decade, severe reflux esophagitis (RE) were observed 2-3 times more frequently. Barrett’s esophagus, a pre-malignant condition, develops in 10-20 % of patients with RE. In addition, it was found that gastroesophageal reflux occupy an important place in the genesis of a number of ENT-diseases and pulmonary diseases. Substantial progress was achieved in the diagnosis and treatment of GERD. The introduction of a 24-hour pH-metry allowed to diagnose the disease at a stage when the endoscopy not reveal visible change in the esophageal mucosa. Widespread use of new drugs in clinical practice, especially proton pump inhibitors (PPIs), has significantly enhanced the treatment of the disease, even in severe GERD. At the same time, practitioners and patients themselves underestimate the importance of this disease. Patients see a doctor late, and are treated oneself even in severe symptoms. Physicians, in turn, know little about the disease, underestimate its impact, and administrate irrational therapy of RE.

gastroesophageal reflux disease, pathogenesis, diagnosis, extraesophageal manifestations and complications of gastroesophageal reflux disease, treatment, proton pump inhibitors, rabeprazole