HEREDITARY HEMOCHROMATOSIS (CASE REPORT)


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The article presents 2 clinical cases of genetically confirmed hereditary hemochromatosis. The main criteria for diagnosis and treatment of this disease are given. In case of presence of cytolytic syndrome, it is necessary to include hemochromatosis in the diagnostic search. It is emphasized that timely and rational treatment of hemochromatosis can prevent the development of liver cirrhosis and significantly increase the life expectancy of patients.

Толық мәтін

Рұқсат жабық

Авторлар туралы

N. Voloshina

Novosibirsk State Medical University

Email: navo@ngs.ru
MD, Prof. at the Department of Propaedeutics of Internal Diseases

Yu. Venzhina

Novosibirsk City Clinical Hospital №.12

N. Kazakova

Novosibirsk City Clinical Hospital №.12

I. Voloshina

Center of New Medical Technologies, Novosibirsk

Әдебиет тізімі

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  7. Moretti D., van Doorn G.M., Swinkels D.W., Melse-Boonstra A. Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic review. Am. J. Clin. Nutr. 2013;98:468-79.
  8. Delatycki M.B., Gurrin L.C., Ong S.Y., Ramm G.A., Anderson G.J., Olynyk J.K., Allen K.J., Nicoll A.J., Powell L.W. Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials. J. Hepatology. 2015;63:282-83.
  9. Phatak P., Brissot P., Wurster M., et al. A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis. Hepatology. 2010;52:1671.
  10. Stefashyna O., Stefashyna O., Stern M., Infanti L., Holbro A. Pattern of care of blood donors with early-uncomplicated hereditary haemochromatosis in a Swiss blood donation centre. Vox Sanguinis. 2014;106:111-17.
  11. Wood M.J., Powell L.W., Ramm G.A. Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis. Blood. 2008;111: 4456-462.

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