OPTIMIZATION OF PATHOGENETIC THERAPY FOR INFLUENZA

Purpose of the study: to evaluate the activity of peroxidic homeostasis in the case of moderate and severe influenza against the conventional therapy and with the additional use of a preparation with antioxidant properties, 2-ethyl-6-methyl-3-hydroxypyridine succinate. Methods. Patients with moderate and severe influenza were examined in 2 groups: the main group (n=45) and the comparison group (n=47). The comparison group received conventional therapy. The main group in addition to conventional therapy received a preparation with antioxidant properties - 2-ethyl-6-methyl-3-hydroxypyridine succinate. Results. In the case of influenza, a pronounced activity of lipid peroxidation reactions is observed throughout the entire observation period, even with clinical recovery, which is indicated by an excess of diene conjugates (DCo) levels by 1.93 times, diene ketones (DKe) by 2.1 times, and plasma malonic dialdehyde (plMDA) - by 3.76 times. In severe form, DCo levels were 2.48 times higher than control values, DKe - by 3.36 times, and plMDA - by 4.18 times. At a severe form of influenza, the peroxidation product levels were significantly higher than in the case of moderate ones. Deficiency of antioxidant protection was confirmed by low activity of enzymes in both moderate and severe conditions: plasma catalase (plC) level was reduced by 2.9 and 3.7 times, erythrocyte catalase of (erC) - by 1,98 and 2,8 times, superoxide dismutase (SOD) - by 1.4 and 2.0 times, respectively. The use of the drug with an antioxidant action contributed to the relief of clinical manifestations of influenza and the correction of imbalance of peroxide homeostasis. This was confirmed by a decrease in the level of lipid peroxidation products in the case of moderate course: DCo by 29.3%, DKe by 43.1%, plMDA by 42%, erMDA by 19.5%, in severe form: DCo by 21.2%, DKe by 38.3%, plMDA by 21%, erMDA by 16.3%. At the same time, the activity of antioxidant protection enzymes increased: in moderate influenza, plC - by 17.4%, erC - by 94.8%, SOD - by 52.2%; in severe course: plC - by 27%, erC - by 70.6%, SOD -by 74.2%. Conclusions. In the phase of clinical recovery of influenza, the activity of lipid pero-xidation and the deficit of antioxidant protection remain. Complex pathogenetic therapy with the use of 2-ethyl-6-methyl-3-hydroxypyridine succinate had a positive effect, reducing the clinical symptoms of the disease and reducing the activity of lipid peroxidation processes. This was confirmed by a decrease in the level of peroxidic homeostasis products - DKe and DCo, plMDA and erMDA, as well as an increase in the activity of antioxidant system enzymes: SOD, plC and erC. This drug can be recommended in clinical practice as a pathogenetic agent for the correction of oxidative stress in influenza.

influenza, lipid peroxidation, antioxidant protection, intoxication syndrome