Safety of continuous glycemic monitoring system in patients after total duodenopancreatectomy in the early postoperative period. Single-center retrospective cohort study
- Авторлар: Farmanov A.G.1,2, Bublik E.V.1, Vinogradskaya O.I.1, Udovichenko O.V.1, Zilov A.V.1,2, Ryzhkova E.G.1,2, Egorov V.I.1, Fadeev V.V.2, Deunezheva S.M.1, Zhivov A.V.1, Tobianskaya I.E.1
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Мекемелер:
- Ilyinskaya Hospital
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Шығарылым: Том 31, № 2 (2024)
- Беттер: 142-148
- Бөлім: Original articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/632465
- DOI: https://doi.org/10.18565/pharmateca.2024.2.142-148
- ID: 632465
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Background. Among the various types of pancreatogenic diabetes mellitus, the greatest difficulties in glycemic control arise in patients after total duodenopancreatectomy (TDPE). This is associated to the presence of an absolute deficiency of insulin secreted by β-cells and a lack of glucagon secreted by α-cells of the pancreas.
Objective. Evaluation of the safety of using the Guardian Connect continuous glucose monitoring (CGM) system in the early postoperative period in patients after TDPE.
Methods. A retrospective assessment of glucose values recorded in the electronic medical record of 28 patients after TDPE who were followed-up in the clinic from 2020 to 2023 was carried out. In group 1, 13 patients were monitored for glycemic control using the Guardian Connect CGM system (in parallel with the use of a glucometer). In group 2, 15 patients underwent glycemic control only using a glucometer.
Results. Intravenous insulin therapy: glucose levels in group 1 were statistically significantly more likely to be in the target range of 5.6–10.0 mmol/L (p = 0.005) and in the range from 4.3 to 11.6 mmol/L (p=0.001). When assessing the number of hypoglycemia episodes below 3.9 mmol/l, the frequency of this side effect was statistically significantly lower in group 1 (p<0.001). The results of the analysis of episodes of severe hypoglycemia showed a lower frequency in group 1 (p>0.05), but the results were not statistically significant. Subcutaneous insulin therapy: glucose levels in group 1 were statistically significantly more likely to be in the target range of 5.6–10.0 mmol/l (p=0.017) and in the range from 4.3 to 11.6 mmol/l (p = 0.017) compared to group 2. When assessing the number of episodes of hypoglycemia below 3.9 mmol/l, no statistically significant differences were found between groups (p<0.112). There were no episodes of severe hypoglycemia in both groups.
Conclusion. The results of our study demonstrate the safety of use of the CGM system in patients in the early postoperative period after TDPE.
Толық мәтін
Авторлар туралы
A. Farmanov
Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Хат алмасуға жауапты Автор.
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-5700-7663
Endocrinologist, Graduate Student of the Department of Endocrinology, Institute of Clinical Medicine No. 1 n.a. N.V. Sklifosovsky
Ресей, Krasnogorsk, Moscow region; MoscowE. Bublik
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-2998-0893
Ресей, Krasnogorsk, Moscow region
O. Vinogradskaya
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-0271-9727
Ресей, Krasnogorsk, Moscow region
O. Udovichenko
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-2991-7130
Ресей, Krasnogorsk, Moscow region
A. Zilov
Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-3494-8011
Ресей, Krasnogorsk, Moscow region; Moscow
E. Ryzhkova
Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-0069-1692
Ресей, Krasnogorsk, Moscow region; Moscow
V. Egorov
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-8805-7604
Ресей, Krasnogorsk, Moscow region
V. Fadeev
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-3026-6315
Ресей, Moscow
S. Deunezheva
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-3104-3412
Ресей, Krasnogorsk, Moscow region
A. Zhivov
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0009-0009-6916-6328
Ресей, Krasnogorsk, Moscow region
I. Tobianskaya
Ilyinskaya Hospital
Email: a.farmanov@ihospital.ru
ORCID iD: 0009-0000-1381-7210
Ресей, Krasnogorsk, Moscow region
Әдебиет тізімі
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