Safety of continuous glycemic monitoring system in patients after total duodenopancreatectomy in the early postoperative period. Single-center retrospective cohort study

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Abstract

Background. Among the various types of pancreatogenic diabetes mellitus, the greatest difficulties in glycemic control arise in patients after total duodenopancreatectomy (TDPE). This is associated to the presence of an absolute deficiency of insulin secreted by β-cells and a lack of glucagon secreted by α-cells of the pancreas.

Objective. Evaluation of the safety of using the Guardian Connect continuous glucose monitoring (CGM) system in the early postoperative period in patients after TDPE.

Methods. A retrospective assessment of glucose values recorded in the electronic medical record of 28 patients after TDPE who were followed-up in the clinic from 2020 to 2023 was carried out. In group 1, 13 patients were monitored for glycemic control using the Guardian Connect CGM system (in parallel with the use of a glucometer). In group 2, 15 patients underwent glycemic control only using a glucometer.

Results. Intravenous insulin therapy: glucose levels in group 1 were statistically significantly more likely to be in the target range of 5.6–10.0 mmol/L (p = 0.005) and in the range from 4.3 to 11.6 mmol/L (p=0.001). When assessing the number of hypoglycemia episodes below 3.9 mmol/l, the frequency of this side effect was statistically significantly lower in group 1 (p<0.001). The results of the analysis of episodes of severe hypoglycemia showed a lower frequency in group 1 (p>0.05), but the results were not statistically significant. Subcutaneous insulin therapy: glucose levels in group 1 were statistically significantly more likely to be in the target range of 5.6–10.0 mmol/l (p=0.017) and in the range from 4.3 to 11.6 mmol/l (p = 0.017) compared to group 2. When assessing the number of episodes of hypoglycemia below 3.9 mmol/l, no statistically significant differences were found between groups (p<0.112). There were no episodes of severe hypoglycemia in both groups.

Conclusion. The results of our study demonstrate the safety of use of the CGM system in patients in the early postoperative period after TDPE.

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About the authors

A. G. Farmanov

Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-5700-7663

Endocrinologist, Graduate Student of the Department of Endocrinology, Institute of Clinical Medicine No. 1 n.a. N.V. Sklifosovsky

Russian Federation, Krasnogorsk, Moscow region; Moscow

E. V. Bublik

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-2998-0893
Russian Federation, Krasnogorsk, Moscow region

O. I. Vinogradskaya

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-0271-9727
Russian Federation, Krasnogorsk, Moscow region

O. V. Udovichenko

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-2991-7130
Russian Federation, Krasnogorsk, Moscow region

A. V. Zilov

Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-3494-8011
Russian Federation, Krasnogorsk, Moscow region; Moscow

E. G. Ryzhkova

Ilyinskaya Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0003-0069-1692
Russian Federation, Krasnogorsk, Moscow region; Moscow

V. I. Egorov

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-8805-7604
Russian Federation, Krasnogorsk, Moscow region

V. V. Fadeev

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-3026-6315
Russian Federation, Moscow

S. M. Deunezheva

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0000-0002-3104-3412
Russian Federation, Krasnogorsk, Moscow region

A. V. Zhivov

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0009-0009-6916-6328
Russian Federation, Krasnogorsk, Moscow region

I. E. Tobianskaya

Ilyinskaya Hospital

Email: a.farmanov@ihospital.ru
ORCID iD: 0009-0000-1381-7210
Russian Federation, Krasnogorsk, Moscow region

References

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  2. Тарасова Ж.С., Бордин Д.С., Килейников Д.В., Кучерявый Ю.А. Панкреатогенный сахарный диабет: взгляд эндокринолога и гастроэнтеролога. Эффективная фармакотерапия. 2020;16(15):92–100. [Tarasova Zh.S., Bordin D.S., Kileinikov D.V., Kucheryavyi Yu.A. Pancreatogenic diabetes mellitus: the view of an endocrinologist and gastroenterologist. Effektivnaya farmakoterapiya. 2020;16(15):92–100. (In Russ.)]. doi: 10.33978/2307-3586-2020-16-15-92-100.
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  9. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. 11-й выпуск. М., 2023. [Algorithms for specialized medical care for patients with diabetes. Ed. by I.I. Dedov, M.V. Shestakova, A.Yu. Mayorov. 11th issue. Moscow, 2023. (In Russ.)]. Doi: 10.14341/ DM13042.
  10. Buschur E.O., Faulds E., Dungan K. CGM in the Hospital: Is It Ready for Prime Time? Curr Diab Rep. 2022;22(9):451–60. doi: 10.1007/s11892-022-01484-x.
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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Study design

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3. Fig. 2. Post of nursing staff with CareLink system installed (Source: A.G. Farmanov, E.V. Bublik, O.I. Vinogradskaya, O.V. Udovichenko, A.V. Zilov, E.G. Ryzhkova, V.I. Egorov, V.V. Fadeev, S.M. Deunezheva, A.V. Zhivov, /I.E. Tobianskaya, 2022)

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