Znachenie antioksidantnoy terapii v lechenii diabeticheskoy polinevropatii
- Autores: Galstyan K.O1
-
Afiliações:
- Edição: Nº 16 (2012)
- Páginas: 56-59
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279931
- ID: 279931
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
A peripheral nerve lesion, a diabetic polyneuropathy (DPN), is typical late complication of type 1 and 2 diabetes mellitus (DM). The article presents the data on the pathogenetic mechanisms of the nervous system involvement in DM, classification of lesions, and principles of treatment of DPN. Special attention is paid to the use of a-lipoic acid as compound that plays a key role in the antioxidant defense system. The success of the prevention and treatment of DPN involves early detection of this complication and a comprehensive approach, including the normalization of glycemia and the use of drugs affecting the pathogenetic mechanisms of DPN.
Palavras-chave
Texto integral
Bibliografia
- Прихожин В.М. Поражение нервной системы при сахарном диабете. М., 1981. 220 с.
- Анциферов М.Б., Токмакова А.Ю., Галстян Г.Р., Удовиченко О.В. Синдром диабетической стопы. 2002.
- Дедов И.И., Галстян Г.Р., Токмарева А.Ю., Удовиченко О.В. Синдром диабетической стопы/Пособиедля врачей. 2003. С. 12.
- Фаучи Э., Браунвальда Ю. Внутренние болезни по Тинсли Р. Харрисону. Книга шестая. Эндогенные болезни и нарушения обмена веществ. 2005. 2512 с.
- Ziegler D., Hanefeld M., Ruhnau K.J., et al. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alphalipoic acid. A 3-week multicentre randomized conrolled trial (ALADIN study). Diabetologia 1995;38:1425-33.
- Ziegler D., Schatz H., Conrad F., et al. Effects of threatment with the antioxidant alphalipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Diab Care 1997;20:369-73.
- Удовиченко О.В., Грекова Н.М. Диабетическая стопа. М., 2010. С. 61-2.
- Ziegler D., et al. Alfa-Lipotic acid in the treatment of diabetic poliyneuropaty in Germany: Current evidence from clinical trials. Exp Clin Endocrinol Diabetes 1999;107: 421-30.
- Аметов А.С. Сахарный диабет 2 типа. Проблемы и решения. 2011. С. 512-27.
- Древаль. А.В. Сахарный диабет фармакологический справочник + стандарты диагностики и лечения 2012. 457 с.