Vliyanie rozuvastatina na strukturnofunktsional'noe sostoyanie endoteliya u bol'nykh khronicheskoy serdechnoy nedostatochnost'yu ishemicheskoy etiologii

Causes of endothelial dysfunction in chronic heart failure (CHF) are diverse and are associated with a long-term hemodynamic overload conducting arteries, hyperactivation of the renin-angiotensin-aldosterone and sympathetic-adrenal system, which manifests itself a perversion of endothelial dilating response to ordinary stimuli. The aim of the work was to study the structure of endothelial function in patients with chronic heart failure of ischemic etiology during therapy with rosuvastatin. The study found that patients with maladaptive remodeling and CHD, there is a marked vascular remodeling, which manifests itself by a sharp decline in vasoregulating endothelial function. In patients receiving rosuvastatin at a daily dose of 20 mg in patients with chronic heart failure of ischemic etiology in 3 months is a significant improvement in vasoregulating endothelial function, lipid profile and structural parameters of functional cardiac remodeling.

Chronic heart failure, endothelium-dependent vasodilation, left ventricular remodeling, rosuvastatin