Personifitsirovannoe lechenie bol'nykh s sindromom slabosti sinusovogo uzla na osnove individual'nykh osobennostey genotipa


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Resumo

The distribution of genotype and allele frequencies of 4a/4b eNOS gene polymorphism in patients with idiopathic sick sinus syndrome (men, women, probands) compared with the control group was analyzed. Significant predominance of homozygous genotype for a rare 4b allele in all study subgroups was reported. Recommendations for the choice of drug therapy depending on the genotype were discussed.

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Bibliografia

  1. Бурова Н.Н. Синдром слабости синусового узла. Клиническая картина, диагностика, варианты течения и прогноз. Дисс. докт. мед. наук. СПб., 2004. 31 с.
  2. Ватутин Н.Т., Калинкина Н.В., Михальченко Е.В. Синдром слабости синусового узла // Серце і судини 2009. № 1. С. 105-11.
  3. Батьянов И.С., Тимофеева Н.И., Куприянова А.В. и др. Семейный синдром слабости синусового узла // Вестник аритмологии 2000. № 16. С. 71.
  4. Benson DW, Wang DW, Dyment M, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest 2003;112(7):1019-28.
  5. Nof E, Luria D, Brass D, et al. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Circulation 2007;116: 463-70.
  6. Holm H, Gudbjartsson DF, Sulem P, et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nature Genet 2011;43:316-20.
  7. Волосовец А.П., Кривопустов С.П., Мороз Т.С. Роль полиморфизма в гене eNOS в развитии кардиальных дизритмий у детей /1 конгрессу Федераціі педиатрів кран СНД «Дитіна и суспільство: проблеми здоровья, развитку та харчування». Киів, 2009. С. 33.
  8. Casas JP, Bautista LE, Humphries SE, et al. Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease. Dis Markers 2011;31(4): 215-22.
  9. Li YY. Endothelial nitric oxide synthase G894T gene polymorphism and essential hypertension in the Chinese population: a meta-analysis involving 11,248 subjects. Intern Med 2011;50(19):2099-106.

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