Azitromitsin v terapii khronicheskoy obstruktivnoy bolezni legkikh: lechenie i profilaktika obostreniy

Chronic obstructive pulmonary disease (COPD) is one of the most pressing health problems due to the high prevalence, high mortality and significant social-economic loss. The most important factors determining the progression of COPD and reduction of the quality of life of patients include exacerbations. The article considers the etiopathogenesis of COPD exacerbations, possible ways of their treatment and prevention using antibiotics. The place of macrolide antibiotics, especially azithromycin, in the therapy of COPD exacerbations is discussed. It is emphasized that azithromycin plays an important role in the therapy of COPD exacerbations due to broad spectrum of action and a favorable safety profile. In contrast to β-lactam antibiotics, it is effective against the main actual pathogens in COPD exacerbations, including intracellular pathogens, as compared with other macrolides, and has potent activity against Haemophilus influenzae and Pseudomonas aeruginosa. Azithromycin has significant difference from other antibiotics due to unique pharmacokinetics, such as primarily accumulation in high concentrations in the tissues, especially in the cells, and long half-life in the body, that allows its use once time a day with a short course.

chronic obstructive pulmonary disease, exacerbation, antibiotic therapy, macrolides, azithromycin