COMBINED APPLICATION OF ZEEL T AND TRAUMEEL S FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: RESULTS OF MOZArT TRIAL


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Resumo

Osteoarthritis is the most common joint disease and is caused by a number of different factors. To date, there is a considerable clinical experience on the use of conventional therapy of osteoarthrosis; majority of prescription drugs, however, has a number of undesirable side effects and contraindications. The use of antihomotoxic medications solves this problem to a large extent, and it was confirmed in a randomized controlled MOZArT trial. Data of this trial indicate that combined use of Zeel T and Traumeel S can be considered as an effective method of pain relief in knee osteoarthrosis. High safety of the therapy is the apparent advantage of this approach to treatment.

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Sobre autores

G. Batischeva

Voronezh State Medical University n.a. N.N. Burdenko

O. Mubarakshina

Voronezh State Medical University n.a. N.N. Burdenko

Email: mubarakshina@mail.ru
PhD, Teaching Assistant at the Department of Clinical Pharmacology

M. Somova

Voronezh State Medical University n.a. N.N. Burdenko

D. Peshekhonov

Voronezh State Medical University n.a. N.N. Burdenko

Bibliografia

  1. Martel-Pelletier J., Barr A.J., Cicuttini F.M., Conaghan RG., Cooper C., Goldring M.B., Goldring S.R., Jones G., Teichtahl A.J., Pelletier J.P. Osteoarthritis. Nat. Rev. Dis. Primers. 2016;2:16072.
  2. Johnson V.L., Hunter D.J. The epidemiology of osteoarthritis. Best. Pract. Res. Clin. Rheumatol. 2014;28(1):5-15
  3. Braun H.J., Gold G.E. Diagnosis of osteoarthritis: imaging. Bone 2012;51(2):278-88.
  4. Srikanth V.K., Fryer J.L., Zhai G., Winzenberg T.M., Hosmer D., Jones G. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 2005;13(9):769-81.
  5. Wluka A.E., Cicuttini F.M., Spector T.D. Menopause, oestrogens and arthritis. Maturitas. 2000;35(3):183-99.
  6. Zhang Y., Jordan J.M. Epidemiology of Osteoarthritis. Clin. Geriatr. Med. 2010;26(3):355-69.
  7. Blagojevic M., Jinks C., Jeffery A., Jordan K.P. Risk factors for onset of osteo-arthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010;18(1):24-33.
  8. Felson D.T., Lawrence R.C., Dieppe P.A., Hirsch R., Helmick C.G., Jordan J.M., Kington R.S., Lane N.E., Nevitt M.C., Zhang Y., Sowers M., McAlindon T., Spector T.D., Poole A.R., Yanovski S.Z., Ateshian G., Sharma L., Buckwalter J.A., Brandt K.D., Fries J.F. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann. Intern. Med. 2000;133(8):635-46.
  9. Thomas A.C., Hubbard-Turner T., Wikstrom E.A., Palmieri-Smith R.M. Epide-miology of Posttraumatic Osteoarthritis. J. Athl. Train. 2016 May 4 [Epub ahead of print].
  10. Mezhov V., Ciccutini F.M., Hanna F.S., Brennan S.L., Wang Y.Y., Urquhart D.M., Wluka A.E. Does obesity affect knee cartilage? A systematic review of magnetic resonance imaging data. Obes. Rev. 2014;15(2):143-57.
  11. Wandel S., Juni P., Tendal B., Nesch E., Villiger P.M., Welton N.J., Reichenbach S., Trelle S. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network metaanalysis. BMJ. 2010;341:c4675.
  12. Bannuru R.R., Schmid C.H., Kent D.M., VaysbrotE.E., Wong J.B., McAlindon T.E. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann. Intern. Med. 2015;162(1):46-54.
  13. Laine L., Smith R., Min K., Chen C., Dubois R.W. Systematic review: the lower gastrointestinal adverse effects of non-steroidal antiinflammatorydrugs. Aliment. Pharmacol. Ther. 2006;24(5):751-67. Review.
  14. Rostom A., Muir K., Dube C., Jolicoeur E., Boucher M., Joyce J., Tugwell P., Wells G.W. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review. Clin. Gastroenterol. Hepatol. 2007; 5(7):818-28.
  15. Leong R.W., Chan F.K. Drug-induced side effects affecting the gastrointestinal tract. Expert. Opin. DrugSaf. 2006;5(4):585-92.
  16. Arroll B., Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: metaanalysis. BMJ. 2004;328(7444):869.
  17. Общая терапия. Каталог препаратов фирмы «Биологише Хайльмиттель Хеель ГмбХ». 2016.
  18. Fernandes J.C., Martel-Pelletier J., Pelletier J.P. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39(1-2):237-46.
  19. Basini G., Santini S.E., Bussolati S., Grasselli F. Sanguinarine inhibits VEGF-induced Akt phosphorylation. Ann. N. Y. Acad. Sci. 2007;1095:371-76.
  20. Stancikovâ M., Bély M., Švík K., Metelmann H.W., Schmolz M.W., Ištok R., Fano R. Effects of Zeel comp. on experimental osteoarthritis in rabbit knee. Rheumatologia. 1999;13(3):101-8.
  21. Schmolz M., Heine H. Homöopathische Substanzen aus der antihomotoxischen Medizin modulieren die Synthese von TGF-ß1 in menschlichen Vollblutkulturen. Biol. Med. 2001;30(2):61-5.
  22. Lozada C., del Rio E., Reitberg D., et al. A multicenter double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderateto-severe pain associated with OA of the knee. Arthritis Rheumatol. 2014;66(Suppl.):S1266. Abstract no. 2896.

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