Mechanisms of violation of the permeability of the epithelial barrier in inflammatory bowel diseases


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Resumo

There is growing evidence that increased permeability of the epithelial barrier may be important in the pathogenesis of inflammatory bowel disease (IBD). This review examines the current understanding of the structure of the epithelial barrier and the molecular mechanisms underlying increased intestinal permeability. Particular attention is paid to the structural changes of the tight junctions (TJ) and adhesive junctions (AJ) of the colonic epithelial barrier in IBD patients.

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Sobre autores

G. Tarasova

Rostov State Medical University; Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Rostov Region

Rostov-on-Don, Russia

A. Iakovlev

Rostov State Medical University; Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Rostov Region

Rostov-on-Don, Russia

A. Zubova

Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Rostov Region

Rostov-on-Don, Russia

S. Nukhova

Rostov State Medical University; Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Rostov Region

Rostov-on-Don, Russia

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