Complex therapy for acute rhinosinusitis. How to avoid polypharmacy?

Background. The problem of acute bacterial rhinosinusitis (ABR) remains relevant in otorhinolaryngology, despite the existing pharmacological possibilities. One of the reasons for the widespread prevalence and increasing incidence is associated with irrational approaches to treatment. In addition to antibiotics, there is an excessive use of drugs of various types or polypharmacy in many cases. In this regard, it remains relevant to study various treatment regimens with the justified inclusion of certain drugs. Objective. Evaluation of the effectiveness of Sinuforte in the treatment of patients with moderate acute rhinosinusitis. Methods. The study included 114 patients (59 women, 55 men) aged 20 to 63 years old (mean age - 41.5±6.2 years) with a diagnosis of moderate ABR, confirmed by clinical and anamnestic data and the results of laboratory and instrumental research methods. Depending on the tactics of treatment, the patients were randomized into two groups. In the main group (MG), the treatment regimen included the use of Sinuforte, 1 dose (1.3 mg) 1 time per day as an intranasal spray for 7 days. In the comparison group (CG), patients used only irrigation of the nasal cavity in combination with decongestants for 7 days. The effectiveness of the treatment was assessed on the 3rd and 7th days and was determined by the degree of decrease in subjective and objective symptoms of ABR according to a 10-point system using a visual analogue scale (VAS), mucociliary clearance (saccharin test) and dynamics of the X-ray patterns. Results. According to the results obtained, the severity of subjective sensations of ABR, as well as objective symptoms, presented in points, on the 7th day were significantly lower in the MG. The dynamics of a decrease in the radiological signs of rhinosinusitis and an improvement in mucociliary clearance in the MG were similar, which by the end of the study was expressed in the achievement of statistical significance between the groups according to these indicators (p<0.05). Conclusion. The results of this study confirm the high efficacy and safety of treatment regimen antibiotic+Sinuforte in patients with moderate ABR. This treatment regimen is characterized by the absence of side effects and allows to achieve recovery in a shorter time.

acute rhinosinusitis, Sinuforte, conservative treatment