Acute tonsilliti in pediatric age: diagnostics and treatment


如何引用文章

全文:

详细

In childhood beta-hemolytic streptococcus group A is causative agent of acute tonsillitis only in one-third of children, same frequency is observed in diseases caused by Epstein-Barr virus and respiratory viruses (most adenoviruses). Clinical differences between these forms of tonsillitis are almost exclusively absence catarrhal symptoms in streptococcal tonsillitis and the presence of nasopharyngitis in patients with viral forms, as well as conjunctivitis in adenovirus. Laboratory markers of bacterial inflammation show minor aid in the differential diagnosis of bacterial and viral forms, dramatize the importance of streptococci identification by microbiological and serological methods. Antibacterial therapy is justified only in streptococcal forms, in which it gives immediate effect. The lack of effect suggests a viral tonsillitis, and stop treatment with antibiotics. The deta-lactams use in streptococcal tonsillitis requires a 10-day course of therapy. Azithromycin or better - jozamycin (less often develops resistance) use allows the 5-day course of therapy.

参考

  1. Гаращенко Т.И. Макролиды в терапии острого тонзиллита и его осложнений у детей // РМЖ. 2001. Т. 9. № 19. С. 812-6.
  2. Белов Б.С. Острая ревматическая лихорадка и хроническая ревматическая болезнь сердца: диагностика, лечение, профилактика // Consilium Medicum. 2006. Т. 1. № 4. С. 614-8.
  3. Bisno AL, Gerber MA, Gwaltney JM, et al. Diagnosis and management of group A streptococcal pharyngitis: a practical guideline. Clin Infect Dis 1997;25:574-83.
  4. Насонова В.А., Белов Б.С., Страчунский Л.С. и др. Антибактериальная терапия стрептококкового тонзиллита и фарингита // Клин. микробиол. антимикроб. химиотер. 1999. № 1. С. 78-82.
  5. Пискунов Г.З., Анготоева И.Б. Острый тонзиллофарингит // Леч. врач. 2007. № 2. С. 70-5.
  6. McIsaac WJ, Goel V, To T, et al. The validity of sore throat score in family practice. CMAJ 2000;163(7):811-5.
  7. Leung AK, Newman R, Kumar A, et al. Rapid antigen detection testing in diagnosing group A beta-hemolytic streptococcal pharyngitis. Expert Rev Mol Diagn 2006 ;6(5):761-6.
  8. Edmonson MB, et al. Relationship between clinical likelihood of group А Streptococcal pharyngitis and the sensitivity of rapid antigen-detection test in pediatric practice. Pediatrics 2005;115:280-5.
  9. Данилюк Н. К. Вирус Эпштейна-Барр и серодиагностика связанных с ним заболеваний // Новости "Вектор-Бест" (информ. бюлл.). 2000. № 4. С. 18.
  10. Putto-Laurila A, Mertsola J, Ruuskanen O. Viral Causes of Tonsillitis and Fever Unresponsive To Antibiotic Therapy. Pediatr Infect Dis J 1999;18(1):71-2.
  11. Белов Б.С., Гришаева Т.П. Современные аспекты А-стрептококкового тонзиллита // Вопросы совр. педиатр. 2003. Т. 2, № 4. С. 40-6.
  12. Сидоренко С.В., Грудинина С.А., Филимонова О.Ю. и др. Резистентность к макролидам и линкозамидам среди Streptococcus pneumoniae и Streptococcus pyogenes в Российской Федерации //Клин. фармакол. тер. 2008. Т. 17. № 2. С. 1-4.
  13. Portier H, Bourrillon A, Lucht F, et al. Treatment of acute group A beta-hemolytic streptococcal tonsillitis in children with a 5-day course of josamycin. Arch Pediatr 2001;8(7):700-6.
  14. Кречиков В.А., Катосова Л.К., Копытко Л. Н. и др. Сравнение микробиологической клинической эффективности 7- и 10-дневного курса джозамицина при стрептококковом тонзиллофарингите у детей: предварительные результаты российского многоцентрового исследования // Клин. микробиол. антимикроб. химиотер. 2009. Т. 11. № 2. Приложение 1. С. 21.
  15. Pickering LK. Red book 2006. Report of the Committee on Infectious diseases. American Academу of Pediatrics Elk Grove Village. Ill. 27th ed. 2006.
  16. Tanz RR. Convenient schedules and short course treatment of acute streptococcal pharyngitis. Pediatr Infect Dis J 2000;19(6):569-70.
  17. Pessey JJ, Gehanno P, Thoroddsen E, et al. Short course therapy with cefuroxime axetil for acute otitis media: results of a randomized multicenter comparison with amoxicillin/clavulanate. Pediatr Infect Dis J 1999;18(10):854-9.
  18. Pichichero ME, Gooch WM, Rodriguez W, et al. Effective short-course treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis. Ten days of penicillin V vs 5 days or 10 days of cefpodoxime therapy in children. Arch Pediatr Adolesc Med 1994;148(10):1053-60.
  19. Pichichero M E, Casey JR, Mayes T, et al. Penicillin failure in streptococcal tonsillopharyngitis: causes and remedies. Pediatr Infect Dis J 2000;19(9):917-923.
  20. Schaad UB, Kellerhals P, Altwegg M. The swiss pharyngitis study group. Azithromycin versus penicillin V for treatment of acute group A streptococcal pharyngitis. Pediatr Infect Dis J 2002;21(4):304-8.
  21. Cohen R, Reinert P, De La Rocque F, et al. Comparison of two dosages of azithromycin for three days versus penicillin V for ten days in acute group A streptococcal tonsillopharyngitis. Pediatr Infect Dis J 2002;21(4):297-303.
  22. Altamimi S, Khalil A, Khalaiwi KA, et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev 2009;21(1):CD004872.
  23. Sharland M, Kendall H, Yeates D, et al. Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis and rheumatic fever in children: time trend analysis. BMJ 2006;331-28.

补充文件

附件文件
动作
1. JATS XML

版权所有 © Bionika Media, 2009
##common.cookie##