MIFEPRISTONE FOR LABOR PREINDUCTION AND INDUCTION


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In modern obstetrics, preparations of the cervix for childbirth and labor induction are widespread. In our country, mifepristone is one of the main drugs for labor preinduction and induction. The article presents the results of study aimed to evaluation of mifepristone effectiveness for preparation of uterine cervix for childbirth and labor induction, with assessment of characteristics of act of delivery, the frequency of cesarean section and perinatal outcomes. The effectiveness of mifepristone in cervical ripening was 83%, and the majority of women had vaginal delivery. Childbirth was characterized by reduction of labor abnormalities and shorter duration of labor in multiparous women. In addition, it was shown that mifepristone may be successfully used in outpatient settings.

参考

  1. Heikinheimo O. Clinical pharmacokinetics of mifepristone. Clin Pharmacokinet 1997;33(1):7-17.
  2. Prairie BA, Lauria MR, Kapp N, et al. Mifepristone versus laminaria: a randomized controlled trial of cervical ripening in midtrimester termination. Contraception 2007;76(5):383-88.
  3. Calder A, Alfirevic Z, Baxter J, et al. Induction of labour. Clinical guideline. 2008. 104 р.
  4. McGill J, Shetty A. Mifepristone and misoprostol in the induction of labor at term. Int J Gynaecol Obstet 2007;96(2):80-4.
  5. Gallot D, de Lapasse C, Houlle C, et al. Obstetrical prognosis of labour induction with mifepristone after 41 weeks of gestation. Gynecol Obstet Fertil 2004;32(9):708-12.
  6. Hapangama D, Neilson JP. Mifepristone for induction of labour. Cochrane Database Syst Rev 2009;3:CD002865.
  7. Fassett MJ, Wing DA. Uterine activity after oral mifepristone administration in human pregnancies beyond 41 weeks' gestation. Gynecol Obstet Invest 2008;65(2):112-15.
  8. Wing DA, Fassett MJ, Mishell DR. Mifepristone for preinduction cervical ripening beyond 41 weeks' gestation: a randomized controlled trial. Obstet Gynecol. 2000;96(4):543-48.
  9. Miao MH, Gao ES, Chen AM, et al. Mifepristone-induced abortion and duration of third stage labour in a subsequent pregnancy. Paediatr Perinat Epidemiol 2010;24(2):125-30.
  10. Giacalone PL, Daurés JP, Faure JM, et al. The effects of mifepristone on uterine sensitivity to oxytocin and on fetal heart rate patterns. Eur J Obstet Gynecol Reprod Biol 2001;97(1):30-4.
  11. Jiang X, Wang H, Zhang Z. Determination of fetal umbilical artery flow velocity during induction of term labor by mifepristone. Zhonghua Fu Chan Ke Za Zhi 1997;32(12):732-34.
  12. Berkane N, Verstraete L, Uzan S, et al. Use of mifepristone to ripen the cervix and induce labor in term pregnancies. Am J Obstet Gynecol 2005;192(1):114-20.

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