CARDIORENAL RELATIONSHIPS IN PATIENTS WITH PRIMARY HYPOTHYROIDISM DEPENDING ON THE PHASE OF DISEASE

The article presents the results of the evaluation of cardiorenal relationships in 187 patients with primary hypothyroidism of various etiologies at different phases of the disease taking into account the degree of thyroid insufficiency. All patients were diagnosed with such hemodynamic changes as left ventricular hypertrophy, diastolic dysfunction, decreased endothelium-dependent endothelial function, increased intima-media thickness, and decreased glomerular filtration rate (GFR). There was a significant relationship between GFR and age, thyroid-stimulating hormone level, systolic blood pressure, total cholesterol and low density lipoprotein cholesterol levels. Close relationships identified illustrate the fact of probable presence of cardiorenal syndrome in patients with primary hypothyroidism, and make it reasonable to include the dynamic evaluation of renal filtration function in standards for diagnosis and treatment of primary hypothyroidism, regardless of the phase of the disease, particularly in patients with concomitant cardiovascular pathology, taking into account the possible development of chronic kidney disease.

primary hypothyroidism, cardiorenal syndrome, lipid metabolism, cardiovascular disease, renal filtration function