Vol 14, No 4 (2017)


Clinical Manual for Diagnosis, Prevention and Treatment of Cardiovascular Complications of Cancer Therapy. Parts II-V

Chazova I.Y., Tyulyandin S.A., Vitsenia M.V., Poltavskaya M.G., Gilyarov M.Y., Martynyuk T.V., Ovchinnikov A.G., Panchenko E.P., Fedotkina Y.A., Stenina M.B., Trophimova O.P., Ageev F.T.


Advances in treatment have led to improved survival of patients with cancer but have also resulted in untoward side effects associated with treatment. Cardiovascular diseases are one of the most frequent of these side effects. Myocardial dysfunction and heart failure, myocardial ischaemia, arrhythmias, arterial hypertension, thromboembolic disease and other cardiovascular complications can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. This manual discusses concepts for timely diagnosis, intervention, and surveillance of patients treated with cardiotoxic cancer therapies. In this second part оf manual we discuss the diagnostic, prevention and treatment aspects of cancer therapy-related coronary artery disease, arterial hypertension, arrhythmias and pulmonary hypertension.
Systemic Hypertension. 2017;14(4):6-19
pages 6-19 views

Regulatory adaptive status in determining the effectiveness of nebivololum and sotalolum in patients with hypertensive disease and paroxysmal supraventricular tachycardia

Nazhalkina N.M., Tregubov V.G., Pokrovsky V.M.


Objective. Compare the effectiveness of treatment with nebivololum or sotalolum in patients with paroxysmal supraventricular tachycardia (SVT) on a background of essential hypertension (EH) taking into account quantitative evaluation of the regulatory adaptive status (RAS). Materials and methods. 49 patients with paroxysmal SVT against the background of EH of stages II-III took part in the research, they were randomized into two groups for treatment with nebivololum (7.4±1.9 mg/day n=25) or sotalolum (162.5±46.2 mg/day n=24). As part of combination therapy, patients were administered lisinoprilum (14.4±4.4 and 14.3±4.7 mg/day), when required also atorvastatinum (15.9±4.1 mg/day, n=9 and 16.0±4.8 mg/day, n=10), acetylsalicylic acid (93.1±16.2 mg/day, n=14 и 94.1±16.5 mg/day, n=14). Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, controlled arterial hypertension, effectively suppressed paroxysms of SVT, improved the quality of life. At the same time, the use of nebivololum increased the RAS and increased exercise tolerance to a greater degree than the use of sotalolum. Conclusion. In patients with paroxysmal SVT against the background of EH of stages II-III, the use of nebivololum as part of combination therapy may be preferable to sotalolum due to its positive impact on the RAS.
Systemic Hypertension. 2017;14(4):20-26
pages 20-26 views

Features of the use of torasemide in arterial hypertension

Baryshnikova G.A., Chorbinskajya S.A.


The article deals with the choice of diuretic in arterial hypertension and presents data on the antihypertensive efficacy of the loop diuretic torasemide. Data on the mechanisms of antihypertensive action of torasemide are presented, including a unique antialdosterone effect. The article reports on the absence of a negative effect of the drug on carbohydrate, lipid, purine metabolism and electrolyte balance, positive effect on the target organs, very good tolerability. It is advisable to use torasemide more widely in a "non-diuretic" dose (2.5-5 mg / day) for the treatment of arterial hypertension as in monotherapy as in combination with other antihypertensive drugs.
Systemic Hypertension. 2017;14(4):27-31
pages 27-31 views

Relationship between selected populations of leukocytes and cardiovascular system activity in women with essential hypertension

Kuznik B.I., Davydov S.O., Guseva E.S., Stepanov A.V., Smolyakov Y.N., Tsybikov N.N., Fine I.V., Magen E.


Objective. To investigate the effect of the quantitative ratios of different types of white blood cells on the cardiovascular system in healthy individuals and patients with essential hypertension (EH). Materials and methods. The study was performed on 102 women suffering EH. The control group consisted of 30 healthy patients. Results. In women with EH, both non-engaged (EH-1) and regularly engaged in kinesitherapy (EH-2), compared with the control group, the total content of leukocytes was increased, as well as the ratios of NEUTR/EOS, LYM/EOS, LYM/BAS and EOS/BAS. In hypertensive patients increased stroke volume and end-diastolic left ventricular volume, cardiac output, increased mass and the index of left ventricular mass. In EH-1 patients group, the balance of velocity distribution in the microcirculatory bed changes to fast interlayer processes. In patients with EH-2, these changes are much less pronounced. In healthy women and patients with EH, significant relationships between leukocyte ratios and the level of systolic diastolic, mean, pulse pressure, cardiohemodynamics, hemodynamic indices were found. Conclusion. Regular practice of kinesitherapy brings the condition of cardiohemodynamics, hemodynamic indices, as well as the investigated correlations to the characteristic of healthy women. These data suggest an important role of the relationship of various leukocyte populations in the pathogenesis of EH.
Systemic Hypertension. 2017;14(4):32-37
pages 32-37 views

Modern concepts of the relationship between obesity and erectile dysfunction in patients with arterial hypertension

Alekseeva T.A., Litvin A.Y.


In this article, we will consider the main modern concepts of obesity, as well as the definition, severity, prevalence and its pathogenetic features. The review will present various methods for diagnosing obesity, including laboratory diagnostics and visualization methods. The role of biomarkers of adipose tissue in the diagnosis of obesity will be considered. The advantages and disadvantages of various visualization methods for diagnosing obesity will be described in detail. Also in the article epidemiology, etiology and pathogenesis of erectile dysfunction will be described, diagnostic possibilities depending on the etiological factors of this pathology will be considered. Details of the relationship between erectile dysfunction and obesity in patients with arterial hypertension will be given. In this review a cascade of hormonal and metabolic disorders, leading to the formation of a vicious circle in patients with obesity erectile and dysfunction will be considered. The data of the results of both international and domestic research are given. In conclusion, erectile dysfunction is presented as an independent predictor of cardiovascular disasters.
Systemic Hypertension. 2017;14(4):38-43
pages 38-43 views

Markers of early target-organ brain damage in essential arterial hypertension: the search continues. Possibilities of diffusion tensor magnetic resonance imaging

Parfenov V.A., Ostroumova T.M., Ostroumova O.D., Perepelova E.M., Perepelov V.A.


The article touches upon the issue of brain as an end-organ target of essential arterial hypertension (AH). The article gives current information about the possibilities and potential clinical application of diffusion-tensor magnetic resonance imaging for the earliest assessment of white matter damage in patients with essential AH. Dataare presented upon the reduction of fractional anisotropy in hypertensive patients and its correlation with blood pressure level.
Systemic Hypertension. 2017;14(4):44-49
pages 44-49 views

Markers of early target-organ brain damage in essential arterial hypertension: the search continues. Possibilities of diffusion tensor magnetic resonance imaging

Anikin G.S., Storozhuk I.K., Filyazova Y.Y.


Rosuvastatin is one of the most frequently prescribed drugs for primary and secondary prevention of myocardial infarction and stroke. The present article deals with the main studies confirming the effectiveness of rosuvastatin in patients with different cardiovascular risks.
Systemic Hypertension. 2017;14(4):50-54
pages 50-54 views

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