GOODPASTURE SYNDROME: FEATURES OF PATHOGENESIS, APPROACHES TO THE DIAGNOSIS AND TREATMENT


Cite item

Full Text

Abstract

The present article discusses the features of pathogenesis and course of Goodpasture syndrome, as well as approaches to its diagnosis and treatment

About the authors

N A Mukhin

References

  1. Мухин Н.А. Синдром Гудпасчера. В кн.: И.Е. Тареева (ред.) Нефрология (руководство для врачей). М., 2000.
  2. Bosch X., Font J. The pulmonary-renal syndrome: a poorly understood clinicopathologic condition. Lupus. 1999; 8: 258-262.
  3. Алмазов В.А., Журавлев В.А., Наймарк Д.А., Петров М.Н. Капиллярит с преимущественным поражением сосудов почек и легких (синдром Goodpasture) // Клиническая медицина. 1972. № 10. С. 140-145.
  4. Uezu Y., Kiyatake I., Tokuyama K. A case of Goodpasture's syndrome with massive pulmonary hemorrhage ameliorated by cyclophosphamide pulse therapy. Nippon Jinzo Gakkai Shi. 1999; 41: 499-504.
  5. Daly C., Conlon P.J., Medwar W. et al. Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Ren. Fail. 1996; 18: 105-112.
  6. Shah M.K., Hugghins S.Y. Characteristics and outcomes of patients with Goodpasture's syndrome. South. Med. J. 2002; 95: 1411-1418.
  7. Hirayama K., Yamagata K., Kobayashi M. et al. Anti-glomerular basement membrane antibody disease in Japan: part of the nationwide rapidly progressive glomerulonephritis survey in Japan. Clin. Exp. Nephrol. 2008; 12(5): 339-347.
  8. von Vigier R.O., Trummler S.A., Laux-End R. et al. Pulmonary renal syndrome in childhood: a report of twenty-one cases and a review of the literature. Pediatr. Pulmonol. 2000; 29: 382-388.
  9. Bergs L. Goodpasture syndrome. Crit. Care Nurs. 2005; 25: 50-58.
  10. Hammerschmidt D.E. Ernest Goodpasture and glomerulonephritis. J. Lab. Clin. Med. 2002; 139: 324.
  11. Murphy T.E. A case report of Goodpasture syndrome is described and discussed in terms of insurability. J. Insur. Med. 2000; 32: 189-190.
  12. Jung C., Karpouzas G., Stringer W.W. Dyspnea, hemoptysis, and perihilar infiltrates in a 35-year-old man. Chest. 2005; 127: 1437-1441.
  13. Calderon E.J., Wichmann I., Varela J.M. et al. Presence of glomerular basement membrane (GBM) antibodies in HIV-patients with Pneumocystis carinii pneumonia. Clin. Exp. Immunol. 1997; 107: 448-450.
  14. Tsagalis G.C., Margelos V., Nikolopoulou N., Hadjiconstantinou V.E. Fluctuating levels of anti-GBM antibodies following a fungal infection in a patient with secondary amyloidosis. Clin. Nephrol. 2003; 59: 150-152.
  15. Lucas Guillen E., Martinez Ruiz A., Alegria Fernandez M. et al. Goodpasture syndrome: re-exacerbations associated with intercurrent infections. Rev. Clin. Esp. 1995; 195: 761-764.
  16. Turner-Warwick M. Adverse reactions affecting the lung: possible association with D-penicillamine. J. Rheumatol. Suppl. 1981; 7: 166-168.
  17. Derk C.T., Jimenez S.A. Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature. J. Rheumatol. 2003; 30: 1616-1620.
  18. Gaskin G., Thompson E.M., Pusey C.D. Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment. Nephrol. Dial. Transplant. 1995; 10: 1925-1928.
  19. Stetter M., Schmidl M., Krapf R. Azathioprine hypersensitivity mimicking Goodpasture's syndrome. Am. J. Kidney Dis. 1994; 23: 874-877.
  20. Shah M.K. Outcomes in patients with Goodpasture's syndrome and hydrocarbon exposure. Ren. Fail. 2002; 24: 545-555.
  21. Garcia-Rostan y Perez G.M., Garcia Bragado F., Puras Gil A.M. Pulmonary hemorrhage and antiglomerular basement membrane antibody-mediated glomerulonephritis after exposure to smoked cocaine (crack): a case report and review of the literature. Pathol. Int. 1997; 47: 692-697.
  22. Sirvent A.E., Enriquez R., Andrada E. et al. Goodpasture's syndrome in a patient using cocaine - a case report and review of the literature. Clin. Nephrol. 2007; 68(3): 182-185.
  23. Kalluri R., Petrides S., Wilson C.B. et al. Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. Ann. Intern. Med. 1996; 124: 651-653.
  24. Au W.Y., Tang S.C., Chan K.W. et al. Pulmonary renal syndrome and thrombotic thrombocytopenic purpura in a patient with giant cavernous hemangioma of the leg. Arch. Intern. Med. 2002; 162: 221-222.
  25. Gandhi S., Little M.A., Farrington K. Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome. Ren. Fail. 2004; 26(5): 591-596.
  26. Persson U., Hertz J.M., Carlsson M. et al. Patients with Goodpasture's disease have two normal COL4A3 alleles encoding the NC1 domain of the type IV collagen alpha 3 chain. Nephrol. Dial. Transplant. 2004; 19: 2030-2035.
  27. Rees A.J., Peters D.K., Compston D.A. et al. Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome. Lancet 1978; 2: 966.
  28. Kitagawa W., Imai H., Komatsuda A. et al. The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease. Nephrol. Dial. Transplant. 2008; 23(10): 3126-3129.
  29. Kose H., Sado Y., Yamada T. et al. Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats. Exp. Anim. 2009; 58(2): 193-198.
  30. Zhou X.J., Lv J.C., Yu L. et al. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese. Nephrol. Dial. Transplant. 2009 Jul 29. [Epub ahead of print]
  31. Ball J.A., Young K.R. Pulmonary manifestations of Goodpasture's syndrome. Antiglomerular basement membrane disease and related disorders. Clin. Chest. Med. 1998; 19: 777-791.
  32. Rutgers A., Meyers K.E., Canziani G. et al. High affinity of anti-GBM antibodies from Goodpasture and transplanted Alport patients to alpha3(IV)NC1 collagen. Kidney Int. 2000; 58: 115 - 122
  33. Hudson B.G., Tryggvason K., Sundaramoorthy M., Neilson E.G. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N. Engl. J. Med. 2003; 348: 2543-2556.
  34. Hellmark T., Segelmark M., Unger C. et al. Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease. Kidney Int. 1999; 55: 936-944.
  35. Gunnarsson A., Hellmark T., Wieslander J. Molecular properties of the Goodpasture epitope. J. Biol. Chem. 2000; 275: 30844 - 30848.
  36. Borza D.B., Neilson E.G., Hudson B.G. Pathogenesis of Goodpasture syndrome: a molecular perspective. Semin. Nephrol. 2003; 23: 522-531.
  37. Wu J., Borillo J., Glass W.F. et al. T-cell epitope of alpha3 chain of type IV collagen induces severe glomerulonephritis. Kidney Int. 2003; 64(4): 1292-1301.
  38. Zou J., Henderson L., Thomas V. et al. Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes. J. Am. Soc. Nephrol. 2007; 18(3): 771-779.
  39. Zhao J. et al. Levels of epitope-specific autoantibodies correlate with renal damage in anti-GBM disease. Nephrol. Dial. Transplant. 2009; 24(6): 1838-1844.
  40. Zhao J., Yan Y., Cui Z. et al. The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3(IV)NC1 is associated with disease severity. Hum. Immunol. 2009; 70(6): 425-429.
  41. Chikamitsu H. Experimentelle studien uber immunocytotoxische glomerulonephritis. Folia Endocrin. Japan 1940; 40: 85Yang R., Hellmark T., Reynolds J., Moss J., Duda M.A. et al. The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease. J. Pathol. 2003; 200: 118-129.
  42. Borza D.B. Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis. Nephron Exp. Nephrol. 2007; 106(2): e37-e43.
  43. Salama A.D., Chaudhry A.N., Ryan J.J. et al. In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV)NC1. J. Am. Soc. Nephrol. 2001; 12: 1908-1915.
  44. Dean E.G., Wilson G.R., Li M. et al. Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney Int. 2005; 67: 566-575.
  45. Nakamura A., Yuasa T., Ujike A. et al. Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J. Exp. Med. 2000; 191: 899-906.
  46. Okada H., Moriwaki K., Kalluri R. et al. Inhibition of monocyte chemoattractant protein-1 expression in tubular epithelium attenuates tubulointerstitial alteration in rat Goodpasture syndrome. Kidney Int. 2000; 57: 927-936.
  47. Taniguchi H., Kojima R., Sade H. et al.Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats. J. Clin. Immunol. 2007; 27(4): 409-429.
  48. Kuroda T., Yoshida Y., Kamiie J. et al.Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats. Clin. Exp. Nephrol. 2004; 8(3): 206-215.
  49. Collard H.R., Schwarz M.I. Diffuse alveolar hemorrhage. Clin. Chest Med. 2004; 25: 583-592.
  50. Jung C., Karpouzas G., Stringer W.W. Dyspnea, hemoptysis, and perihilar infiltrates in a 35-year-old man. Chest. 2005; 127: 1437-1441.
  51. Ball J.A., Young K.R. Pulmonary manifestations of Goodpasture's syndrome. Antiglomerular basement membrane disease and related disorders. Clin. Chest. Med. 1998; 19: 777-791.
  52. Salama A.D., Levy J.B., Lightstone L., Pusey C.D. Goodpasture's disease. Lancet. 2001; 358: 917-920.
  53. Sethi S., Lewin M., Lopez L., Lager D. Linear anti-glomerular basement membrane IgG but no glomerular disease: Goodpasture's syndrome restricted to the lung. Nephrol. Dial. Transplant. 2007; 22(4): 1233-1235.
  54. Le Quang C., Delevaux I., Trouillier S. et al. Intra-alveolar haemorrhage without renal damage as the initial presenting feature of Goodpasture's syndrome: case report and review of literature. Rev. Med. Interne. 2008; 29(12): 1038-1042.
  55. Charytan D., MacDonald B., Sugimoto H. et al. An unusual case of pulmonary-renal syndrome associated with defects in type IV collagen composition and anti-glomerular basement membrane autoantibodies. Am. J. Kidney Dis. 2005; 45(4): 743-748.
  56. Borza D.B., Chedid M.F., Colon S. et al. Recurrent Goodpasture's disease secondary to a monoclonal IgA1-kappa antibody autoreactive with the alpha1/alpha2 chains of type IV collagen. Am. J. Kidney Dis. 2005; 45(2): 397-406.
  57. Sengul E., Eyileten T., Ozcan A. et al. Anti-glomerular basement membrane disease with nephrotic proteinuria. Clin. Nephrol. 2009; 72(2): 157-159
  58. Gallagher H., Kwan J.T., Jayne D.R. Pulmonary renal syndrome: a 4-year, single-center experience. Am. J. Kidney Dis. 2002; 39: 42-47.
  59. Kalluri R. Goodpasture syndrome. Kidney Int. 1999; 55: 1120-1122.
  60. Zhao M., Ding J., Liu Y. et al. A clinical and pathological analysis of 41 patients with anti-glomerular basement membrane antibody related diseases. Zhonghua Nei Ke Za Zhi. 2001; 40: 316-320.
  61. Vuckovic B., Ilic T., Mitic I. et al. Goodpasture's syndrome - case report. Med. Pregl. 2004; 57: 391-395.
  62. Sharma S. Bilateral serous retinal detachments associated with Goodpasture's syndrome. Can. J. Ophthalmol. 1998; 33: 226-227.
  63. Chak M., Stanford M.R., Poon W. et al. Uveitis initiating an autoimmune reaction resulting in Goodpasture's syndrome in a Chinese man. Br. J. Ophthalmol. 2002; 86: 1188-1190.
  64. Blanco Filho F., Ernesto L.C., Rosa M.A. et al. Rapidly progressive antineutrophil cytoplasm antibodies associated with pulmonary-renal syndrome in a 10-year-old girl. Sao Paulo Med. J. 2001; 119: 29-32.
  65. Verburgh C.A., Bruijn J.A., Daha M.R. et al. Sequential development of anti-GBM nephritis and ANCA-associated Pauci-immune glomerulonephritis. Am. J. Kidney Dis. 1999; 34: 344-348.
  66. Kalluri R., Meyers K., Mogyorosi A. et al. Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. J. Am. Soc. Nephrol. 1997; 8: 1795-1800.
  67. Serratrice J., Chiche L., Dussol B. et al. Sequential development of perinuclear ANCA-associated vasculitis and anti-glomerular basement membrane glomerulonephritis. Am. J. Kidney Dis. 2004; 43: e26-e30.
  68. Henderson R.D., Saltissi D., Pender M.P. Goodpasture's syndrome associated with multiple sclerosis. Acta Neurol. Scand. 1998; 98: 134-135.
  69. Carreras L., Poveda R., Bas J. et al. Goodpasture syndrome during the course of a Schonlein-Henoch purpura. Am. J. Kidney Dis. 2002; 39: E21.
  70. Drube S., Maurin N., Sieberth H.G. Coincidence of myasthenia gravis and antiglomerular basement membrane glomerulonephritis: a combination of two antibody-mediated autoimmune diseases on day 15. Nephrol. Dial. Transplant. 1997; 12: 1478-1480.
  71. Nakamura T., Suzuki Y., Koide H. Granulocyte and monocyte adsorption apheresis in a patient with antiglomerular basement membrane glomerulonephritis and active ulcerative colitis. Am. J. Med. Sci. 2003; 325: 296-298.
  72. Komatsu T., Utsunomiya K., Oyaizu T. Goodpasture's syndrome associated with primary biliary cirrhosis. Intern. Med. 1998; 37: 611-613.
  73. Takeuchi K., Takeda T., Sakai I. et al. An autopsy case of Goodpasture syndrome preceded with membranous glomerulonephritis. Ryumachi. 1997; 37: 781-787.
  74. Kielstein J.T., Helmchen U., Netzer K.O. et al. Conversion of Goodpasture's syndrome into membranous glomerulonephritis. Nephrol. Dial. Transplant. 2001; 16: 2082-2085.
  75. Thitiarchakul S., Lal S.M., Luger A., Ross G. Goodpasture's syndrome superimposed on membranous nephropathy. A case report. Int. J. Artif. Organs. 1995; 18: 763-765.
  76. Hecht N., Omoloja A., Witte D. et al. Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis. Pediatr. Nephrol. 2008; 23(3): 477-480.
  77. Gartenschlager M., Lenci G., Schinzel H. et al. Goodpasture syndrome: treatment initiation with plasmapheresis before histologic diagnostic verification. Pneumologie. 1996; 50: 764-768.
  78. Laczika K., Knapp S., Derfler K. et al. Immunoadsorption in Goodpasture's syndrome. Am. J. Kidney Dis. 2000; 36: 392-395.
  79. Baumgartner I., Gmur J., Fontana A. et al. Recovery from life threatening pulmonary hemorrhage in Goodpasture's syndrome after plasmapheresis and subsequent pulse dose cyclosphosphamide. Clin. Nephrol. 1995; 43: 68-70.
  80. Garcia-Canton C., Toledo A., Palomar R. et al. Goodpasture's syndrome treated with mycofenolat mofetil. Nephrol. Dial. Transplant. 2000; 15: 920-922.
  81. Takeda S., Takahashi M., Sado Y. et al. Prevention of glomerular crescent formation in glomerulonephritis by mycophenolate mofetil in rats. Nephrol. Dial. Transplant. 2004; 19(9): 2228-2236.
  82. Asgeirsdottir S.A., Zwiers P.J., Morselt H.W. et al. Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. Am. J. Physiol. Renal. Physiol. 2008; 294(3): F554-F561.
  83. Garcia G.E., Truong L.D., Li P. et al. Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis. Am. J. Pathol. 2007; 170(5): 1485-1496.
  84. Huang L., Garcia G., Lou Y. et al. Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis. Am. J. Pathol. 2009; 174(4): 1368-1378.
  85. Ma F.Y., Flanc R.S., Tesch G.H. et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab. Invest. 2009; 89(4): 470-484.
  86. Rops A.L., Gotte M., Baselmans M.H. et al. Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis. Kidney Int. 2007; 72(10): 1204-1215.
  87. Levidiotis V., Freeman C., Tikellis C. et al. Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease. Nephrology (Carlton). 2005; 10(2): 167-173.
  88. Leh S., Vaagnes O., Margolin S.B. et al. Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats. Nephrol. Dial. Transplant. 2005; 20(1): 71-82.
  89. Netzer K.O., Merkel F., Weber M. Goodpasture syndrome and end-stage renal failure - to transplant or not to transplant? Nephrol. Dial. Transplant. 1998; 13: 1346-1348.
  90. Miyazato M., Koyama Y., Miyazato T. et al. Cadaveric renal transplantation for Goodpasture's syndrome: a case report. Hinyokika Kiyo. 2001; 47: 493-495.
  91. Hibbs A.M., Bznik-Cizman B., Guttenberg M. et al. Ulcerative colitis in a renal transplant patient with previous Goodpasture disease. Pediatr. Nephrol. 2001; 16: 543-546.
  92. Khandelwal M., McCormick B.B., Lajoie G. et al. Recurrence of anti-GBM disease 8 years after renal transplantation. Nephrol. Dial. Transplant. 2004; 19(2): 491-494.
  93. Sauter M., Schmid H., Anders H.J. et al. Loss of a renal graft due to recurrence of anti-GBM disease despite rituximab therapy. Clin. Transplant. 2009; 23(1): 132-136.
  94. Saurina A., Arrizabalaga P., Rodriguez R. et al. Anti-glomerular basement membrane antibody mediated disease: revision of 32 cases and follow-up at one year of the diagnosis. Nefrologia. 2003; 23: 415-422.
  95. Segelmark M., Hellmark T., Wieslander J. The prognostic significance in Goodpasture's disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. Nephron. Clin. Pract. 2003; 94: c59-c68.
  96. Schindler R., Kahl A., Lobeck H. et al. Complete recovery of renal function in a dialysis-dependent patient with Goodpasture syndrome. Nephrol. Dial. Transplant. 1998; 13: 462-466.
  97. Schmidt R.H., Sieh S., Rohl D. et al. Spontaneous remission of Goodpasture syndrome in a 21-year-old patient. Dtsch. Med. Wochenschr. 1999; 124: 1201-1203.
  98. Levy J.B., Turner A.N., Rees A.J. et al. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann. Intern. Med. 2001; 134: 1033-1042.
  99. Merkel F., Pullig O., Marx M. et al. Course and prognosis of anti-basement membrane antibody (anti-BM-Ab)-mediated disease: report of 35 cases. Nephrol. Dial. Transplant. 1994; 9: 372-376.
  100. Cui Z., Zhao M.H., Xin G. et al. Characteristics and prognosis of Chinese patients with anti-glomerular basement membrane disease. Nephron Clin. Pract. 2005; 99: c49-c55.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies