NEPHROPROTECIVE AND CARDIOPROTECTIVE EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME INHIBITOR IN PATIENTS WITH HYPERTENSIVE NEPHROPATHY
- Authors: Nanchikeeva ML1, Kozlovskaya LV1
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Affiliations:
- Issue: No 6 (2010)
- Pages: 25-33
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245917
- ID: 245917
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Abstract
Aim. Assessment of nephroprotective and cardioprotective efficacy of ACE inhibitors in patients with hypertensive nephropathy.
Methods. 72 patients with arterial hypertension stage II - III with chronic kidney disease (age 18 - 65 years) were included into the study. Dynamics of microalbuminuria, estimated glomerular filtration rate (eGFR), Doppler renal hemodynamics parameters, as well as left ventricular mass index (LVMI) and intima-media thickness in common carotid artery (IMT) were assessed during therapy with ACE-inhibitors and lifestyle modification of associated risk factors.
Results. ACE inhibitors demonstrated cardioprotective and nephroprotective efficacy in patients with goal blood pressure (BP) achieved. In those patients, in whom BP did not reach target levels, IMT and LVMI tended to increase.
Conclusion. ACE inhibitors can be possess nephroprotective and cardioprotecive effects, especially if target BP levels were achieved
Methods. 72 patients with arterial hypertension stage II - III with chronic kidney disease (age 18 - 65 years) were included into the study. Dynamics of microalbuminuria, estimated glomerular filtration rate (eGFR), Doppler renal hemodynamics parameters, as well as left ventricular mass index (LVMI) and intima-media thickness in common carotid artery (IMT) were assessed during therapy with ACE-inhibitors and lifestyle modification of associated risk factors.
Results. ACE inhibitors demonstrated cardioprotective and nephroprotective efficacy in patients with goal blood pressure (BP) achieved. In those patients, in whom BP did not reach target levels, IMT and LVMI tended to increase.
Conclusion. ACE inhibitors can be possess nephroprotective and cardioprotecive effects, especially if target BP levels were achieved
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