CHRONIC KIDNEY DISEASE AND PROGNOSIS IN PATIENTS WITH CHRONIC HEART FAILURE
- Authors: Makeeva ER1, Troshen'kina OV1, Khiteva SV1
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Affiliations:
- Issue: No 6 (2010)
- Pages: 54-56
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245959
- ID: 245959
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Abstract
Aim. Study of influence of chronic kidney disease (CKD) on prognosis, hospitalization rate and healthcare costs in patients with chronic heart failure (CHF).
Methods. 308 patients (167 male and 141 female, mean age 57,8±10,8 years) were included into the study, duration of observation was 60 months. The main (193 patients) etiology of CHF was association of coronary heart disease and arterial hypertension. CHF I (NYHA) was diagnosed in 86, CHF II (NYHA) - in 180, CHF III (NYHAP - in 37, CHF IV (NYHA) - in 5. 47 patients had diabetes mellitus type 2. Glomerular filtration rate (GFR) was estimated according to MDRD formula.
Results. CKD with eCGF <60 ml/min/1,73m2 was found in 108 (35,1%) CHF patients. CKD was associated with increase of total mortality (relative risk 1,7), number of hospitalizations per 1 patients (0,9 [CI 95% 0,2-4,2] versus 0,7 [CI 95% 0,09-2,5], p<0,02) due to all causes and due to cardiovascular causes (0,9 [CI 95% 0,6-5,2] vesrus 0,6 [CI 95% 0,1-3,0], p<0,02). CKD with eCGF <60 ml/min/1,73m2 costs for hospital care increased for 21%.
Conclusion. CKD in CHF patients was associated with increasing of total mortality, number of hospitalizations and healthcare costs
Methods. 308 patients (167 male and 141 female, mean age 57,8±10,8 years) were included into the study, duration of observation was 60 months. The main (193 patients) etiology of CHF was association of coronary heart disease and arterial hypertension. CHF I (NYHA) was diagnosed in 86, CHF II (NYHA) - in 180, CHF III (NYHAP - in 37, CHF IV (NYHA) - in 5. 47 patients had diabetes mellitus type 2. Glomerular filtration rate (GFR) was estimated according to MDRD formula.
Results. CKD with eCGF <60 ml/min/1,73m2 was found in 108 (35,1%) CHF patients. CKD was associated with increase of total mortality (relative risk 1,7), number of hospitalizations per 1 patients (0,9 [CI 95% 0,2-4,2] versus 0,7 [CI 95% 0,09-2,5], p<0,02) due to all causes and due to cardiovascular causes (0,9 [CI 95% 0,6-5,2] vesrus 0,6 [CI 95% 0,1-3,0], p<0,02). CKD with eCGF <60 ml/min/1,73m2 costs for hospital care increased for 21%.
Conclusion. CKD in CHF patients was associated with increasing of total mortality, number of hospitalizations and healthcare costs
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