Membranoproliferative glomerulonephritis type II. Case, diagnosis and comments
- Authors: Tsygin AN1, Kartamysheva NN1, Shklyaev DP1, Leonova LV1, Povilaytite PE1
-
Affiliations:
- Issue: No 4 (2011)
- Pages: 60-62
- Section: Articles
- URL: https://journals.eco-vector.com/2075-3594/article/view/245987
- ID: 245987
Cite item
Full Text
Abstract
Membranoproliferative glomerulonephritis type II (dense deposit disease) is a rare glomerular disease with a hallmark sign of presence of electron-dense deposits within the glomerular basement membrane. The disease is caused with uncontrolled activation of alternative complement pathway. Some cases have a genetic origin. Childhood is a predominant age of the onset. The article presents a case report with comments
References
- Martinez-Barricarte R., Heurich M., Valdes-Canedo F. et al. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provaides insights into complement activation and regulation. J Clin Invest. 2010; 120(10): 3702-3712.
- Lachmann P.J. The amplification loop of complement pathways. Adv. Immunol. 2009; 104: 115-149.
- Суханов А.В., Румянцев А.Л., Цыгин А.Н.. Мембранопролиферативный гломерулонефрит 2-го типа (болезнь плотных подоцитов) с быстропрогрессирующим течением. Нефрология и диализ 2003; 5 (4): 399-400.
- Appel B. Gerald, Cook Terence H., Hageman G. et al. Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease): An Update. J Am Soc Nephrol. 2005; 16: 1392-1404.
- Smith R.J.H., Alexander J., Barlow P.N. Et al. New Approaches to the Treatment of Dense Deposit Disease. J Am Soc Nephrol. 2007; 18: 2447-2456.
Supplementary files
