The Global Role of Kidney Transplantation


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Abstract

World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost effectiveness. Anything that is both cheaper and better, but is not actually the dominant therapy, must have other drawbacks that prevent replacement of all dialysis treatment by transplantation. The barriers to universal transplantation as the therapy for end stage kidney disease include the economic limitations which, in some countries place transplantation, appropriately, at a lower priority than public health fundamentals such as clean water, sanitation and vaccination. Even in high income countries the technical challenges of surgery and the consequences of immunosuppression restrict the number of suitable recipients, but the major finite restrictions on kidney transplantation rates are the shortage of donated organs and the limited medical, surgical and nursing workforces with the required expertise. These problems have solutions which involve the full range of societal, professional, governmental and political environments. World Kidney Day is a call to deliver transplantation therapy to the one million people a year who have a right to benefit.

About the authors

- Gul'ermo Garsiya Garsiya

Nephrology Service, Hospital Civil de Guadalajara, University of Guadalajara Health Sciences Center (CUCS)Hospital 278,Guadalajara, Jal. 44280, MEXICO

Nephrology Service, Hospital Civil de Guadalajara, University of Guadalajara Health Sciences Center (CUCS)Hospital 278,Guadalajara, Jal. 44280, MEXICO

- Pol Kharden

Oxford Kidney Unit and Oxford Transplant Centre, Churchill Hospital, Oxford, United Kingdom

Oxford Kidney Unit and Oxford Transplant Centre, Churchill Hospital, Oxford, United Kingdom

- Dzheremi Chapmen

Centre for Transplant and Renal Research, Westmead Millennium Institute, Sydney University, Westmead Hospital, Sydney, NSW, 2145, Australia

Centre for Transplant and Renal Research, Westmead Millennium Institute, Sydney University, Westmead Hospital, Sydney, NSW, 2145, Australia

- Guillermo Garcia Garcia

- Paul Harden

- Jeremy Chapman

References

  1. Murray JE <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Murray%20JE%22%5BAuthor%5D>. Ronald Lee Herrick Memorial: June 15, 1931-December 27, 2010. Am J Transplant. <http://www.ncbi.nlm.nih.gov/pubmed/21342441> 2011 Mar;11(3):419.
  2. http://www.anzdata.org.au/anzdata/AnzdataReport/33rdReport/Ch08.pdf. Accessed 29/11/2011 <http://www.anzdata.org.au/anzdata/AnzdataReport/33rdReport/Ch08.pdf.%20Accessed%2029/11/2011>.
  3. Shimmura H, Tanabe K, Ishida H, Tokumoto T, Ishikawa N, Miyamoto N, Shirakawa H, Setoguchi K, Nakajima I, Fuchinoue S, Teraoka S, Toma H. Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO-blood type antibody titers under our current immunosuppression. <http://www.ncbi.nlm.nih.gov/pubmed/16249749> Transplantation. 2005 Oct 15;80(7):985-8.
  4. Peng A, Vo A, Jordan SC. Transplantation of the highly human leukocyte antigen-sensitized patient: long-term outcomes and future directions Transplantation Reviews 2006; 20: 46-156
  5. Warren DS, Montgomery RA. Incompatible kidney transplantation: lessons from a decade of desensitization and paired kidney exchange. <http://www.ncbi.nlm.nih.gov/pubmed/20087679> Immunol Res. 2010 Jul;47(1-3):257-64.
  6. Weber CLC, Rush DN, Jeffery JR, Cheang M, Karpinski ME. Kidney transplantation outcomes in Canadian aboriginals. Am J Transplantation 2006;6:1882-1889.
  7. Gordon EJ, Ladner DP, Caicedo JC, Franklin J. Disparities in kidney transplant outcomes: A review . SeminNephrol 2010;30:81-89.
  8. Collins JF. Kidney disease in Maori and Pacific people in New Zealand. ClinNephrol 2010;74:S61-S65.
  9. Rizvi SAH, Naqvi SAA, Zafar MN, Hussain Z, Hashmi A, Hussain M, Akhtar F, Ahmed E. Living related renal transplants with lifelong follow-up. A model for the developing world. ClinNephrol 2010; 74: supppl 1 :S142-149.
  10. Monteon FJ, Gomez B, Valdespino C, Chavez S, Sandoval M, Flores A, et al.Thekidneytransplantexperience at Hospital de Especialidades, Centro Mйdico Nacional de Occidente, IMSS, Guadalajara Mйxico. <http://www.ncbi.nlm.nih.gov/pubmed/15387108>ClinTraspl 2003;165-174
  11. Jha V. Current status of end-stage disease care in South Asia. Ethn Dis 2009; 1: suppl 1:S27-S32).
  12. Wolfe RA, Ashby VB, Milford EL, et al.Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation and recipients of a first cadaveric transplant. New Eng J Med 1999;341:1725-30.
  13. Sakhuja V, Sud K. End-stage renal disease in India and Pakistan: Burden of disease and management issues. Kidney Int 2003; 83: S115-8.
  14. Rizvi SAH, Naqvi SAA, Zafar MN et al.A Renal Transplantation Model for developing countries. Am J Transplant 2011: 11: 2302-2307.
  15. Sud K et al. Indian J of Nephrology 1999; 9: 83-91.
  16. Meier-Kriesche HU, Kaplan B. Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes. Transplantation 2002;74(10):1377-81.
  17. Kasiske BL, Snyder JJ, Matas MD, et al.Pre-emptive kidney transplantation: The advantage and the advantaged. J Am SocNephrol 2002;13:1358-6.
  18. http://www.who.int/transplantation/knowledgebase/en/ Accessed 29/11/2011
  19. Yeates K. Health Disparities in renal disease in Canada. SeminNephrol 2010;30:12-18
  20. Alexander GC, Sehgal AR. Barriers to cadaveric renal transplantation among blacks, women, and the poor. JAMA 1998;280:1148-1152
  21. McDonald S. Incidence and treatment of ESRD among indigenous peoples of Australasia. Clin Nephrol 2010;74: suppl 1:S28-31.
  22. Garcia-Garcia G, Renoirte-Lopez K, Marquez-Magaña I. Disparities in renal care in Jalisco, Mexico. SeminNephrol 2010;30:3-7.
  23. Gordon EJ, Ladner DP, Caicedo JC, Franklin J. Disparities in kidney transplant outcomes: A review . SeminNephrol 2010;30:81-89.
  24. rd Global WHO ConsultationMarch 2010. OrganDonation and Transplantation: Striving to Achieve Self-Sufficiency. Transplantation 2011; 91 11S June 15: S27-S114.
  25. Bernat JJ, D'Alesandro AM, Port FK, Bleck TP, Heard SO et al. Report of a National conferenceondonationaftercardiacdeath. Amer J Transplant 2006; 6: 281-291.
  26. Abraham G, John GT, Sunil S, Fernando EM, Reddy YNV. Evolution of renal transplantation in India over the last four decades. NDT Plus 2010; 3:203-207.
  27. Shimazono Y <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Shimazono%20Y%22%5BAuthor%5D>Thestate of the international organ trade: a provisional picture based on integration of available information. Bull World Health Organ. <http://www.ncbi.nlm.nih.gov/pubmed?term=shimazono%20Yosuke> 2007 Dec;85(12):955-62.
  28. World Health Assembly 44/1991/REC/1. Annex 6
  29. World Health Assembly 63.22/2010 <http://www.who.int/transplantation/Guiding_PrinciplesTransplantation_WHA63.22en.pdf>Accessed 29/11/2011.
  30. Participants in the International Summit on Transplant Tourism and Organ Trafficking Convened by the Transplantation Society and International Society of Nephrology in Istanbul, Turkey, April 30-May 2, 2008.The Declaration of Istanbul on organ trafficking and transplant tourism. <http://www.ncbi.nlm.nih.gov/pubmed/18946336> Transplantation. 2008 Oct 27;86(8):1013-8.
  31. Delmonico FL, Domínguez-Gil B, Matesanz R, Noel L. A call for government accountability to achieve national self-sufficiency in organ donation and transplantation. Lancet. 2011 Oct 15.
  32. UnitedNations General Assembly. Political declaration of the High-level Meeting of the General Assembly on the Prevention and Control of Non-communicable Diseases A/66/L.1, September 16, 2011

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