Tubulo-interstitial involvement in kidney disease in patients with infective endocarditis


Cite item

Full Text

Abstract

Aim. Assessment of incidence and severity of renal tubulo-interstitial damage in patients with infective endocarditis (IE) with kidney involvement.
Methods. 41 patients with IE were included into the study. In all patients albuminuria, urine level of α-2-microglobulin, activity of γ-glutamiltransferase (γ-GT) - enzyme of the brush border of tubular epithelium, mitochondrial enzyme lactatdehydrogenase (LDH), as well as markers of systemic inflammation - serum C-reactive protein and circulating immune complexes concentrations were determined.
Results. Patients with IE were characterized by significant elevation of enzymuria and urine α-2-microglobulin level; this parameters were highest in those patients, who received aminoglicozydes or vancomycin. Signs of glomerular and tubulo-interstitial involvement correlated with intensity of systemic inflammatory responce.
Conclusion. Patients with IE are characterized with renal tubulo-interstital involvement, associated with systemic inflammatory response, glomerulonephritis and decrease of renal function.

References

  1. Чипигина Н.С., Виноградова Т.Л., Тимофеев В.Т., Большакова М.А., Барышева С.А.. Поражение почек при инфекционном эндокардите. Клиницист 2008; 4:16-23
  2. Андросова Т. В., Таранова М. В., Козловская Л.В. Особенности течения и лечения инфекционного эндокардита. Врач 2008; (6):21-23
  3. Moreillon P., Que Y. Infective endocarditis. Lancet 2004; 363: 139-149.
  4. Николаевский Е.Н., Хубулава Г.Г., Авраам Г.Х., Детюченко В.П. Современные аспекты клинико-морфологической картины острого и подострого инфекционного эндокардита. Клин мед 2007;(4):27-30.
  5. Комаров В.Т., Татарченко И.П., Савченко Р.П. и др. Клинико-лабораторная характеристика поражения почек при инфекционном эндокардите. Нефрология 2000;(4):52-7.
  6. Kirkpantur A., Altinbas A., Arici M. et al. Enterococcal endocarditis associated with crescentic glomerulonephritis. Clin Exp Nephrol 2007;11(4):321-5.
  7. Majumdar A., Chowdhary S., Ferreira M. et al. Renal pathological findings in infective endocarditis. Nephrol Dial Transplant 2000;15:1782-7.
  8. Karchmer A.W. Infective Endocarditis.In: Braunwald's Heart Disease. A Textbook of Cardiovascular Medicine. D.P. Zipes et al., eds.7th ed. Philadelphia: WB Saunders Co, 2005. p. 1633-58.
  9. Е.М. Лукьянова Нефротоксичность антибиотиков у новорожденных. Качеств. клиническая практика 2002; 2: 53-62
  10. Kasama R., Sorbello A. Renal and electrolyte complications associated with antibiotic therapy. Am Fam Physician 1996; 53 ; (1 Suppl.): 227S-32S.
  11. Habib G., Hoen B., Tornos P., et al.; ESC Committee for Practice Guidelines. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J 2009; 30(19): 2369-413.
  12. Herget-Rosenthal S, Poppen D, Husing J, Marggraf G, Pietruck F, Jakob HG, Philipp T, Kribben A: Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin Chem 2004; 50:552- 558
  13. Smith G.C., Winterborn M.H., Taylor C.M., et al. Assessment of retinol-binding protein excretion in normal children. Pediatr Nephrol 1994; 8: 148-50.16
  14. Fanos V., Padovani E.M. Importance of evaluation of urinary enzymes and microglobulins in the neonatal period [in Italian] UP 1995; 6: 775-83.12
  15. Мазуров В.И., Уланова В.И. Течение инфекционного эндокардита у инъекционных наркоманов и лиц с предрасполагающими заболеваниями сердца. Клин мед 2001;(8):23-8

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies